WDR46 - WD repeat domain 46 Gene

Also Known as UTP7; BING4; FP221; C6orf11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9277

About WDR46

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,279,108-33,289,239 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 188 orthologues. Ubiquitous expression in appendix (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR46 Products (2)

mRNA	Protein	Name
NM_001164267.2	NP_001157739.1	WD repeat-containing protein 46 isoform 2
NM_005452.6	NP_005443.3	WD repeat-containing protein 46 isoform 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR46 Protein Structure

WD40

BING4CT

0
100
200
300
400
500
610 a.a.

Protein Preferred Names	Protein Names
WD repeat-containing protein 46	WD repeat-containing protein BING4

Related Diseases

Diseases	Alias
Asthma, Nasal Polyps, And Aspirin Intolerance	Asthma And Nasal Polyps Asa Triad Asthma, Aspirin-Induced, Susceptibility To Asthma, Aspirin-Induced Asthma, With Nasal Polyps And Aspirin Intolerance ANPAI Aia Aspirin-Intolerant Asthma Asthma Aspirin-Induced Nasal Polyps Asthma And Aspirin Sensitivity Samter Triad Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15782	WDR46 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WDR46	VGNC	VGNC:78940
Rattus norvegicus	WDR46	RGD	RGD:2209
Mus musculus	WDR46	MGD	MGI:1931871
Felis catus	WDR46	VGNC	VGNC:67036
Canis familiaris	WDR46	VGNC	VGNC:48369
Bos taurus	WDR46	VGNC	VGNC:36902
Others	WDR46	NCBI