NDST3 - N-deacetylase and N-sulfotransferase 3 Gene

Also Known as HSST3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9348

About NDST3

Cytogenetic location: 4q26 Genomic coordinates (GRCh38): 4:118,033,322-118,258,634 (from NCBI)

This gene has 2 transcripts (splice variants), 330 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

NDST3 Products (1)

mRNA Protein Name
NM_004784.3 NP_004775.1 bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IDA
IDA: Inferred from direct assay
9915799 GOA
enables heparan sulfate N-deacetylase activity IDA
IDA: Inferred from direct assay
9915799 GOA
Biological Process GO Annotation Evidence References Source
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
9915799 GOA
involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IDA
IDA: Inferred from direct assay
9915799 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDST3 Protein Structure

HSNSD

HSNSD: heparan sulfate-N-deacetylase (20 - 506)

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (596 - 844)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 873 a.a.
Protein Preferred Names Protein Names

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3

  • GlcNAc N-deacetylase/ N-sulfotransferase 3

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09120 NDST3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDST3 VGNC VGNC:68436
Bos taurus NDST3 VGNC VGNC:53768
Macaca mulatta NDST3 VGNC VGNC:75152
Mus musculus NDST3 MGD MGI:1932544
Canis familiaris NDST3 VGNC VGNC:43683
Rattus norvegicus NDST3 RGD RGD:1310960
Others NDST3 NCBI