ARHGAP18 - Rho GTPase activating protein 18 Gene

Also Known as SENEX; MacGAP; bA307O14.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93663

About ARHGAP18

Cytogenetic location: 6q22.33 Genomic coordinates (GRCh38): 6:129,576,132-129,710,177 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 22.0), lung (RPKM 16.4) and 25 other tissues.

Summary

ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]

ARHGAP18 Products (1)

mRNA Protein Name
NM_033515.3 NP_277050.2 rho GTPase-activating protein 18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
21865595 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21865595 GOA
involved in regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
21865595 GOA
involved in regulation of cell motility IMP
IMP: Inferred from mutant phenotype
21865595 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
21865595 GOA
involved in regulation of small GTPase mediated signal transduction IMP
IMP: Inferred from mutant phenotype
21865595 GOA
involved in small GTPase-mediated signal transduction IMP
IMP: Inferred from mutant phenotype
21865595 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
21865595 GOA
located in cytoplasmic microtubule IDA
IDA: Inferred from direct assay
28251925 GOA
located in ruffle IDA
IDA: Inferred from direct assay
28251925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP18 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (343 - 489)

  • 0
  • 200
  • 400
  • 600
  • 663 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 18

  • rho-type GTPase-activating protein 18

Related Diseases

Diseases Alias
Hemoglobin E Disease

  • Hemoglobin E

  • Hb-E Disease
Aortic Aneurysm, Familial Thoracic 1

  • Thoracic Aortic Aneurysm

  • Annuloaortic Ectasia

  • Familial Thoracic Aortic Aneurysm And Aortic Dissection

  • Familial Aortic Dissection

  • Familial Taad

  • Familial Thoracic Aortic Aneurysm

  • Congenital Aneurysm Of Ascending Aorta

  • Familial Aortic Aneurysm

  • Familial Thoracic Aortic Aneurysm And Dissection

  • Aortic Aneurysm, Thoracic

  • AAT1

  • Faa1

  • Aortic Dissection, Familial

  • Aortic Aneurysm, Familial Thoracic

  • Aneurysm, Thoracic Aortic

  • Faa

  • Ftaad

  • Taa

  • Taad

  • Cystic Medial Necrosis Of Aorta

  • Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

  • Aortic Aneurysm Thoracic

  • Familial Aortic Aneurysms

  • Aneurysm, Aortic, Thoracic, Familial, Type 1

  • Aneurysm Of Thoracic Aorta

  • Intrathoracic Aneurysm

  • Thoracic Aorta Aneurysm

  • Thoracic Aortic Aneurysm Without Rupture

  • Thoracic Aneurysm

  • Thorax Arterial Aneurysm

  • Thoracic Artery Aneurysm

  • Thoracic Arterial Aneurysm

  • Thorax Aneurysm

  • Thorax Aortic Aneurysm

  • Dissection Of Thoracic Aorta
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00918 ARHGAP18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGAP18 VGNC VGNC:38049
Macaca mulatta ARHGAP18 VGNC VGNC:69875
Felis catus ARHGAP18 VGNC VGNC:59878
Bos taurus ARHGAP18 VGNC VGNC:26078
Rattus norvegicus ARHGAP18 RGD RGD:1305053
Mus musculus ARHGAP18 MGD MGI:1921160
Others ARHGAP18 NCBI