Pard3 - par-3 family cell polarity regulator Gene

Also Known as Asip; Par3; Phip; Par-3; Pard-3; Pard3a; D8Ertd580e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 93742

Summary

Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein Phosphatase binding activity. Involved in several processes, including negative regulation of peptidyl-threonine phosphorylation; positive regulation of myelination; and positive regulation of receptor internalization. Acts upstream of or within several processes, including apical constriction; centrosome localization; and wound healing, spreading of cells. Located in several cellular components, including Schmidt-Lanterman incisure; internode region of axon; and lateral loop. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and respiratory system. Orthologous to human PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Apr 2022]

Pard3 Products (8)

mRNA	Protein	Name
NM_001013580.4	NP_001013598.1	partitioning defective 3 homolog isoform 2
NM_001013581.3	NP_001013599.1	partitioning defective 3 homolog isoform 1
NM_001122850.2	NP_001116322.1	partitioning defective 3 homolog isoform 4
NM_001309391.1	NP_001296320.1	partitioning defective 3 homolog isoform 5
NM_001309392.1	NP_001296321.1	partitioning defective 3 homolog isoform 6
NM_001363431.1	NP_001350360.1	partitioning defective 3 homolog isoform 7
NM_001363432.1	NP_001350361.1	partitioning defective 3 homolog isoform 8
NM_033620.2	NP_296369.2	partitioning defective 3 homolog isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10954424	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apical constriction	IGI IGI: Inferred from genetic interaction	21685893	MGI
acts upstream of or within centrosome localization	IMP IMP: Inferred from mutant phenotype	19540120	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	19540120	MGI
involved in myelination in peripheral nervous system	IMP IMP: Inferred from mutant phenotype	21949390	MGI
involved in negative regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	21949390	MGI
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	21949390	MGI
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	23354168	MGI
acts upstream of or within regulation of actin filament-based process	IGI IGI: Inferred from genetic interaction	21685893	MGI
acts upstream of or within wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	19540120	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in adherens junction	IDA IDA: Inferred from direct assay	12203721	MGI
located in apical junction complex	IDA IDA: Inferred from direct assay	22512338	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	10954424	MGI
located in cell junction	IDA IDA: Inferred from direct assay	19540120	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	15775979	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	15766746	MGI
located in internode region of axon	IDA IDA: Inferred from direct assay	21949390	MGI
located in lateral loop	IDA IDA: Inferred from direct assay	20237282	MGI
located in spindle	IDA IDA: Inferred from direct assay	15766746	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
partitioning defective 3 homolog	atypical PKC isotype-specific-interacting protein ephrin-interacting protein par-3 (partitioning defective 3) homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10037	PARD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pard3	NCBI	NCBI:56288