2. Gene
  3. SLC22A8 - solute carrier family 22 member 8 Gene

SLC22A8 - solute carrier family 22 member 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OAT3

Gene ID: 9376 | Gene type: protein coding

About SLC22A8

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,992,824-63,015,841 (from NCBI)

This gene has 10 transcripts (splice variants), 313 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 184.6).

Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

SLC22A8 Products(4)

mRNA Protein Name
NM_001184732.2 NP_001171661.1 organic anion transporter 3 isoform 1
NM_001184733.2 NP_001171662.1 organic anion transporter 3 isoform 2
NM_001184736.2 NP_001171665.1 organic anion transporter 3 isoform 3
NM_004254.4 NP_004245.2 organic anion transporter 3 isoform 1

SLC22A8 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (105 - 502)

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  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

organic anion transporter 3

solute carrier family 22 member 8

hOAT3

Related Diseases

Diseases Alias
Gout

Gouty Arthritis

Articular Gout

Gouty Arthropathy

Arthritis, Gouty

Arthritis Gouty

Idiopathic Gout

Idiopathic Gout, Unspecified Site

Gouty Bursitis

Uratic Arthritis

Gout Nos

Gouty

Gouty Diathesis
Hyperuricemia

Blood Urate Raized

Uricacidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13080 SLC22A8 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC22A8 VGNC VGNC:34732
Macaca mulatta SLC22A8 VGNC VGNC:77422
Rattus norvegicus SLC22A8 RGD RGD:632286
Mus musculus SLC22A8 MGD MGI:1336187
Felis catus SLC22A8 VGNC VGNC:108378
Canis familiaris SLC22A8 VGNC VGNC:46281