SLC22A8 - solute carrier family 22 member 8 Gene

Also Known as OAT3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9376

About SLC22A8

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,992,824-63,015,841 (from NCBI)

This gene has 10 transcripts (splice variants), 313 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 184.6).

Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

SLC22A8 Products (4)

mRNA Protein Name
NM_001184732.2 NP_001171661.1 organic anion transporter 3 isoform 1
NM_001184733.2 NP_001171662.1 organic anion transporter 3 isoform 2
NM_001184736.2 NP_001171665.1 organic anion transporter 3 isoform 3
NM_004254.4 NP_004245.2 organic anion transporter 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
11907186 GOA
enables prostaglandin transmembrane transporter activity IDA
IDA: Inferred from direct assay
11907186 GOA
enables solute:inorganic anion antiporter activity IDA
IDA: Inferred from direct assay
15037815 GOA
enables xenobiotic transmembrane transporter activity IDA
IDA: Inferred from direct assay
11669456 GOA
Biological Process GO Annotation Evidence References Source
involved in prostaglandin transport IDA
IDA: Inferred from direct assay
11907186 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
31791063 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15037815 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A8 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (105 - 502)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

organic anion transporter 3

solute carrier family 22 member 8

  • hOAT3

Related Diseases

Diseases Alias
Gout

  • Gouty Arthritis

  • Articular Gout

  • Gouty Arthropathy

  • Arthritis, Gouty

  • Arthritis Gouty

  • Idiopathic Gout

  • Idiopathic Gout, Unspecified Site

  • Gouty Bursitis

  • Uratic Arthritis

  • Gout Nos

  • Gouty

  • Gouty Diathesis
Hyperuricemia

  • Blood Urate Raized

  • Uricacidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13080 SLC22A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SLC22A8 VGNC VGNC:34732
Macaca mulatta SLC22A8 VGNC VGNC:77422
Rattus norvegicus SLC22A8 RGD RGD:632286
Mus musculus SLC22A8 MGD MGI:1336187
Felis catus SLC22A8 VGNC VGNC:108378
Canis familiaris SLC22A8 VGNC VGNC:46281
Others SLC22A8 NCBI