SLC22A13 - solute carrier family 22 member 13 Gene

Also Known as OAT10; OCTL1; OCTL3; ORCTL3; ORCTL-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9390

About SLC22A13

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,265,812-38,278,757 (from NCBI)

This gene has 3 transcripts (splice variants), 325 orthologues and 22 paralogues. Restricted expression toward kidney (RPKM 6.8).

Summary

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

SLC22A13 Products (1)

mRNA Protein Name
NM_004256.4 NP_004247.2 solute carrier family 22 member 13

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nicotinate transmembrane transporter activity EXP
EXP: Inferred from Experiment
18411268 GOA
enables nicotinate transmembrane transporter activity IDA
IDA: Inferred from direct assay
18411268 GOA
enables urate transmembrane transporter activity IDA
IDA: Inferred from direct assay
18411268 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of fatty acid metabolic process IDA
IDA: Inferred from direct assay
24769897 GOA
involved in nicotinate transport IDA
IDA: Inferred from direct assay
18411268 GOA
involved in positive regulation of T cell mediated cytotoxicity directed against tumor cell target IDA
IDA: Inferred from direct assay
19282870 GOA
involved in urate transport IDA
IDA: Inferred from direct assay
18411268 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19282870 GOA
located in apical plasma membrane IDA
IDA: Inferred from direct assay
18411268 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19282870 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19282870 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A13 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (140 - 508)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 551 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 13

  • organic anion transporter 10

Related Diseases

Diseases Alias
Nephrolithiasis, Uric Acid

  • Nephrolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Urolithiasis

  • Uric Acid Nephrolithiasis

  • UAN

  • Acute Urate Nephropathy

  • Urolithiasis, Uric Acid

  • Urolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Renal Calculus
Gout

  • Gouty Arthritis

  • Articular Gout

  • Gouty Arthropathy

  • Arthritis, Gouty

  • Arthritis Gouty

  • Idiopathic Gout

  • Idiopathic Gout, Unspecified Site

  • Gouty Bursitis

  • Uratic Arthritis

  • Gout Nos

  • Gouty

  • Gouty Diathesis
Renal Glucosuria

  • Renal Glycosuria

  • Familial Renal Glucosuria

  • GLYS

  • Glys1

  • Glycosuria, Renal

  • Glucosuria, Renal

  • Renal Diabetes

  • Familial Renal Glycosuria

  • Sglt2 Deficiency

  • Gly

  • Diabetes Renal
Brown-Vialetto-Van Laere Syndrome 2

  • BVVLS2

  • Rfvt3-Related Riboflavin Transporter Deficiency

  • Rtd3

  • Riboflavin Transporter Deficiency 3

  • Brown-Vialetto-Van Laere Syndrome, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13066 SLC22A13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22071 Slc22a13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC22A13 VGNC VGNC:77593
Rattus norvegicus SLC22A13 RGD RGD:1583222
Canis familiaris SLC22A13 VGNC VGNC:46274
Felis catus SLC22A13 VGNC VGNC:68653
Mus musculus SLC22A13 MGD MGI:2143107
Bos taurus SLC22A13 VGNC VGNC:34721