Fkbp6 - FK506 binding protein 6 Gene

Also Known as 36kDa; FKBP-6; FKBP-36; D5Ertd724e; 1700008G22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94244

Summary

This gene is a member of the FK506-binding protein (FKBP) family. The encoded protein plays a role in male-specific fertility and homologous pairing of chromosomes during meiosis. The protein may also be involved in LINE1 transposon silencing and binding to HSP90 as a co-chaperone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013]

Fkbp6 Products (4)

mRNA Protein Name
NM_001277891.1 NP_001264820.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1
NM_001277892.2 NP_001264821.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 2
NM_001277893.1 NP_001264822.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 3
NM_033571.3 NP_291049.1 inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
22902560 MGI
NOT enables peptidyl-prolyl cis-trans isomerase activity IDA
IDA: Inferred from direct assay
22902560 MGI
Biological Process GO Annotation Evidence References Source
involved in meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
12764197 MGI
involved in piRNA processing IMP
IMP: Inferred from mutant phenotype
22902560 MGI
involved in protein folding IMP
IMP: Inferred from mutant phenotype
22902560 MGI
involved in regulatory ncRNA-mediated gene silencing IMP
IMP: Inferred from mutant phenotype
22902560 MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation IMP
IMP: Inferred from mutant phenotype
22902560 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
12764197 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12764197 MGI
located in cytosol IDA
IDA: Inferred from direct assay
22902560 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
12764197 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inactive peptidyl-prolyl cis-trans isomerase FKBP6

  • 36 kDa FK506-binding protein

  • 36 kDa FKBP

  • PPIase FKBP6

  • immunophilin FKBP36

  • inactive PPIase FKBP6

  • peptidyl-prolyl cis-trans isomerase FKBP6

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04966 FKBP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18709 Fkbp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp6 NCBI NCBI:8468