Cadm3 - cell adhesion molecule 3 Gene

Also Known as BIgR; Necl1; Tsll1; Igsf4b; Necl-1; SynCAM3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 94332

Summary

Enables protein homodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and homophilic cell adhesion via plasma membrane adhesion molecules. Acts upstream of or within protein localization. Located in cell-cell junction and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including intestine; liver; nervous system; neural retina; and olfactory epithelium. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]

Cadm3 Products (3)

mRNA Protein Name
NM_001412814.1 NP_001399743.1 cell adhesion molecule 3 isoform 1 precursor
NM_001412815.1 NP_001399744.1 cell adhesion molecule 3 isoform 2
NM_053199.4 NP_444429.1 cell adhesion molecule 3 isoform 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
15893517 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12826663 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
involved in homophilic cell adhesion via plasma membrane adhesion molecules IDA
IDA: Inferred from direct assay
12826663 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
15893517 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
15893517 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
15741237 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
15741237 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cell adhesion molecule 3

  • TSLC1-like protein 1

  • immunoglobulin superfamily, member 4B

  • nectin-like protein 1

  • nectin-lke 1

  • synaptic cell adhesion molecule 3

Recombinant Cadm3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76756 CADM3 Protein, Mouse (HEK293, His) Q99N28 (N23-H328) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS18510 Cadm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01821 CADM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24992 Cadm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cadm3 NCBI NCBI:57863