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SLC4A7 - solute carrier family 4 member 7 Gene

Also Known as NBC2; NBC3; SBC2; NBCN1; SLC4A6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9497

About SLC4A7

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,372,723-27,484,384 (from NCBI)

This gene has 18 transcripts (splice variants), 276 orthologues and 9 paralogues. Ubiquitous expression in duodenum (RPKM 27.5), small intestine (RPKM 8.8) and 20 other tissues.

Summary

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

SLC4A7 Products (9)

mRNA	Protein	Name
NM_001258379.2	NP_001245308.1	sodium bicarbonate cotransporter 3 isoform b
NM_001258380.2	NP_001245309.1	sodium bicarbonate cotransporter 3 isoform c
NM_001321103.2	NP_001308032.1	sodium bicarbonate cotransporter 3 isoform d
NM_001321104.2	NP_001308033.1	sodium bicarbonate cotransporter 3 isoform e
NM_001321105.2	NP_001308034.1	sodium bicarbonate cotransporter 3 isoform f
NM_001321106.2	NP_001308035.1	sodium bicarbonate cotransporter 3 isoform g
NM_001321107.2	NP_001308036.1	sodium bicarbonate cotransporter 3 isoform h
NM_001321108.2	NP_001308037.1	sodium bicarbonate cotransporter 3 isoform i
NM_003615.5	NP_003606.3	sodium bicarbonate cotransporter 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14736710	GOA
enables sodium:bicarbonate symporter activity	IDA IDA: Inferred from direct assay	10347222	GOA
enables sodium:bicarbonate symporter activity	IMP IMP: Inferred from mutant phenotype	14578046	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	35772404	GOA
involved in phagosome acidification	IDA IDA: Inferred from direct assay	29779931	GOA
involved in purine nucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	35772404	GOA
involved in pyrimidine nucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	35772404	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	17715183	GOA
located in membrane	IDA IDA: Inferred from direct assay	27717805	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	29779931	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	14578046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC4A7 Protein Structure

Band_3_cyto

HCO3_cotransp

0
200
400
600
800
1000
1214 a.a.

Protein Preferred Names	Protein Names
sodium bicarbonate cotransporter 3	bicarbonate transporter

Related Diseases

Diseases	Alias
Corneal Dystrophy, Band-Shaped	Band Keratopathy Band-Shaped Keratopathy
Complex Partial Epilepsy	Epilepsy, Complex Partial Complex Partial Epileptic Seizure Epilepsy, Psychomotor Psychomotor Epilepsy
Intestinal Impaction
Corneal Dystrophy And Perceptive Deafness	Corneal Dystrophy-Perceptive Deafness Syndrome CDPD Harboyan Syndrome Cdpd1 Corneal Dystrophy And Sensorineural Deafness Corneal Endothelial Dystrophy And Perceptive Deafness Corneal Dystrophy With Progressive Deafness Congenital Corneal Dystrophy, Progressive Sensorineural Deafness Corneal Dystrophy With Progressive Hearing Loss Corneal Dystrophy-Perceptive Hearing Loss Syndrome Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes
Renal Tubular Acidosis	Acidosis Renal Tubular Acidosis, Renal Tubular Lightwood-Albright Syndrome Lightwood Syndrome Idiopathic Infantile Hypercalcemia - Mild Form Kidney Tubular Acidosis Renal Tubule Acidosis Kidney Acidosis Renal Acidosis Renal Hyperchloremic Acidosis Rta - [Renal Tubular Acidosis]
Corneal Degeneration	Degenerative Corneal Opacity
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13272	SLC4A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21936	Slc4a7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC4A7	VGNC	VGNC:77606
Canis familiaris	SLC4A7	VGNC	VGNC:46436
Bos taurus	SLC4A7	VGNC	VGNC:34896
Rattus norvegicus	SLC4A7	RGD	RGD:621208
Felis catus	SLC4A7	VGNC	VGNC:65391
Mus musculus	SLC4A7	MGD	MGI:2443878
Others	SLC4A7	NCBI