GAL3ST1 - galactose-3-O-sulfotransferase 1 Gene

Also Known as CST

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9514

About GAL3ST1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,554,635-30,574,665 (from NCBI)

This gene has 22 transcripts (splice variants), 284 orthologues and 3 paralogues. Biased expression in kidney (RPKM 2.0), duodenum (RPKM 1.8) and 9 other tissues.

Summary

Sulfonation, an important step in the metabolism of many drugs, xenobiotics, Hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced Insulin resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GAL3ST1 Products (15)

mRNA Protein Name
NM_001318103.2 NP_001305032.1 galactosylceramide sulfotransferase isoform 1
NM_001318104.2 NP_001305033.1 galactosylceramide sulfotransferase isoform 1
NM_001318105.2 NP_001305034.1 galactosylceramide sulfotransferase isoform 1
NM_001318106.2 NP_001305035.1 galactosylceramide sulfotransferase isoform 1
NM_001318107.2 NP_001305036.1 galactosylceramide sulfotransferase isoform 2
NM_001318108.2 NP_001305037.1 galactosylceramide sulfotransferase isoform 1
NM_001318109.1 NP_001305038.1 galactosylceramide sulfotransferase isoform 3
NM_001318110.2 NP_001305039.1 galactosylceramide sulfotransferase isoform 1
NM_001318111.2 NP_001305040.1 galactosylceramide sulfotransferase isoform 1
NM_001318112.2 NP_001305041.1 galactosylceramide sulfotransferase isoform 1
NM_001318113.2 NP_001305042.1 galactosylceramide sulfotransferase isoform 1
NM_001318114.2 NP_001305043.1 galactosylceramide sulfotransferase isoform 2
NM_001318115.2 NP_001305044.1 galactosylceramide sulfotransferase isoform 1
NM_001318116.2 NP_001305045.1 galactosylceramide sulfotransferase isoform 1
NM_004861.3 NP_004852.1 galactosylceramide sulfotransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables galactosylceramide sulfotransferase activity IDA
IDA: Inferred from direct assay
8830034 GOA
Biological Process GO Annotation Evidence References Source
involved in glycerolipid metabolic process IDA
IDA: Inferred from direct assay
8830034 GOA
involved in sphingolipid metabolic process IDA
IDA: Inferred from direct assay
8830034 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GAL3ST1 Protein Structure

Gal-3-0_sulfotr

Gal-3-0_sulfotr: Galactose-3-O-sulfotransferase (4 - 407)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
Protein Preferred Names Protein Names

galactosylceramide sulfotransferase

  • 3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase

Related Diseases

Diseases Alias
Metachromatic Leukodystrophy

  • Arylsulfatase A Deficiency

  • MLD

  • Arsa Deficiency

  • Sulfatide Lipidosis

  • Metachromatic Leukoencephalopathy

  • Cerebral Sclerosis, Diffuse, Metachromatic Form

  • Cerebroside Sulfatase Deficiency

  • Leukodystrophy, Metachromatic

  • Pseudoarylsulfatase A Deficiency

  • Leukodystrophy Metachromatic

  • Sulfatidosis

  • Metachromatic Leukodystrophy, Late Infantile

  • Metachromatic Leukodystrophy Variant

  • Deficiency Of Cerebroside-Sulfatase

  • Scholz Cerebral Sclerosis

  • Sulfatide Lipoidosis

  • Cerebral Sclerosis Diffuse Metachromatic Form

  • Arylsulfatase A Deficiency Disease

  • Cerebroside Sulphatase Deficiency Disease

  • Greenfield Disease

  • Metachromatic Leukodystrophy, Adult

  • Metachromatic Leukodystrophy, Juvenile

  • Leukodystrophy Metachromatic Adult

  • Leukodystrophy Metachromatic Juvenile

  • Leukodystrophy Metachromatic Late Infantile

  • Metachromatic Leukodystrophy, Adult Type

  • Metachromatic Leukodystrophy, Juvenile Type

  • Metachromatic Leukodystrophy, Infant

  • Greenfield'S Disease
Developmental And Epileptic Encephalopathy 84

  • DEE84

  • Jamuar Syndrome

  • Eiee84

  • Developmental And Epileptic Encephalopathy, 84

  • Epileptic Encephalopathy, Early Ifantile, 84

  • Early Infantile Epileptic Encephalopathy 84

  • Epileptic Encephalopathy, Early Infantile, 84

  • Encephalopathy, Epileptic, Early Infantile, Type 84
Leukodystrophy

  • Leukodystrophies
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05239 GAL3ST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GAL3ST1 VGNC VGNC:107791
Mus musculus GAL3ST1 MGD MGI:1858277
Felis catus GAL3ST1 VGNC VGNC:80441
Canis familiaris GAL3ST1 VGNC VGNC:41076
Rattus norvegicus GAL3ST1 RGD RGD:1583379
Bos taurus GAL3ST1 VGNC VGNC:29213
Others GAL3ST1 NCBI