ENTPD6 - ectonucleoside triphosphate diphosphohydrolase 6 Gene

Also Known as CD39L2; IL6ST2; IL-6SAG; NTPDase-6; dJ738P15.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 955

About ENTPD6

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,195,712-25,228,075 (from NCBI)

This gene has 18 transcripts (splice variants), 204 orthologues and 7 paralogues. Ubiquitous expression in prostate (RPKM 15.7), colon (RPKM 15.3) and 25 other tissues.

Summary

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

ENTPD6 Products (24)

mRNA Protein Name
NM_001114089.4 NP_001107561.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 2
NM_001247.5 NP_001238.3 ectonucleoside triphosphate diphosphohydrolase 6 isoform 1
NM_001317941.3 NP_001304870.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 3
NM_001322378.2 NP_001309307.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 1
NM_001322379.2 NP_001309308.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 4
NM_001322380.2 NP_001309309.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 5
NM_001322381.2 NP_001309310.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 5
NM_001322382.2 NP_001309311.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322383.2 NP_001309312.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322384.2 NP_001309313.1 ectonucleoside triphosphate diphosphohydrolase 6 isoform 6
NM_001322385.2 NP_001309314.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 7
NM_001322386.2 NP_001309315.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 8
NM_001322387.2 NP_001309316.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 9
NM_001322388.2 NP_001309317.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 10
NM_001322389.2 NP_001309318.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 11
NM_001322390.2 NP_001309319.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 12
NM_001322391.2 NP_001309320.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 12
NM_001322392.2 NP_001309321.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 13
NM_001322393.2 NP_001309322.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 14
NM_001322394.2 NP_001309323.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 15
NM_001322395.2 NP_001309324.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 16
NM_001322396.2 NP_001309325.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 17
NM_001322397.2 NP_001309326.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 18
NM_001322398.2 NP_001309327.2 ectonucleoside triphosphate diphosphohydrolase 6 isoform 19

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CDP phosphatase activity IDA
IDA: Inferred from direct assay
14529283 GOA
enables GDP phosphatase activity IDA
IDA: Inferred from direct assay
14529283 GOA
enables IDP phosphatase activity IDA
IDA: Inferred from direct assay
14529283 GOA
enables UDP phosphatase activity IDA
IDA: Inferred from direct assay
14529283 GOA
enables nucleoside diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
14529283 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
11041856 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
11041856 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD6 Protein Structure

GDA1_CD39

GDA1_CD39: GDA1/CD39 (nucleoside phosphatase) family (99 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
Protein Preferred Names Protein Names

ectonucleoside triphosphate diphosphohydrolase 6

  • CD39 antigen-like 2

Related Diseases

Diseases Alias
Malignant Essential Hypertension

  • Accelerated Essential Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04400 ENTPD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ENTPD6 RGD RGD:619725
Macaca mulatta ENTPD6 VGNC VGNC:72227
Felis catus ENTPD6 VGNC VGNC:61882
Mus musculus ENTPD6 MGD MGI:1202295
Bos taurus ENTPD6 VGNC VGNC:58980
Canis familiaris ENTPD6 VGNC VGNC:52876