2. Gene
  3. MTRF1 - mitochondrial translation release factor 1 Gene

MTRF1 - mitochondrial translation release factor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RF1; MRF1; MTTRF1

Gene ID: 9617 | Gene type: protein coding

About MTRF1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:41,216,369-41,312,038 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 2.7), lymph node (RPKM 2.2) and 25 other tissues.

Summary

The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]

MTRF1 Products(4)

mRNA Protein Name
NM_001354073.1 NP_001341002.1 peptide chain release factor 1, mitochondrial
NM_001354074.1 NP_001341003.1 peptide chain release factor 1, mitochondrial
NM_001354076.1 NP_001341005.1 peptide chain release factor 1, mitochondrial
NM_004294.4 NP_004285.2 peptide chain release factor 1, mitochondrial

MTRF1 Protein Structure

PCRF

PCRF: PCRF domain (141 - 254)

RF-1

RF-1: RF-1 domain (288 - 399)

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  • 445 a.a.
Protein Preferred Names Protein Names

peptide chain release factor 1, mitochondrial

MRF-1

Related Diseases

Diseases Alias
Spastic Ataxia 3
Deafness, Aminoglycoside-Induced

Streptomycin Ototoxicity

Deafness, Mitochondrial, Modifier Of

Aminoglycoside-Induced Deafness

Deafness, Streptomycin-Induced

Streptomycin-Induced Deafness

DFNI
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08817 MTRF1 Human Pre-designed siRNA Set A / Unkown
HY-RS08818 MTRF1L Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MTRF1 RGD RGD:1584329
Mus musculus MTRF1 MGD MGI:2384815
Felis catus MTRF1 VGNC VGNC:68354
Canis familiaris MTRF1 VGNC VGNC:43492
Macaca mulatta MTRF1 VGNC VGNC:82191
Bos taurus MTRF1 VGNC VGNC:31750