BZW1 - basic leucine zipper and W2 domains 1 Gene

Also Known as 5MP2; BZAP45; Nbla10236

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9689

About BZW1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,811,589-200,827,338 (from NCBI)

This gene has 13 transcripts (splice variants), 298 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 73.8), adrenal (RPKM 67.5) and 25 other tissues.

Summary

Enables RNA binding activity and Cadherin binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

BZW1 Products (9)

mRNA	Protein	Name
NM_001207067.2	NP_001193996.1	eIF5-mimic protein 2 isoform 1
NM_001207068.3	NP_001193997.1	eIF5-mimic protein 2 isoform 2
NM_001207069.2	NP_001193998.1	eIF5-mimic protein 2 isoform 3
NM_001321688.2	NP_001308617.1	eIF5-mimic protein 2 isoform 1
NM_001321690.1	NP_001308619.1	eIF5-mimic protein 2 isoform 1
NM_001321691.2	NP_001308620.1	eIF5-mimic protein 2 isoform 5
NM_001321693.2	NP_001308622.1	eIF5-mimic protein 2 isoform 6
NM_001321694.2	NP_001308623.1	eIF5-mimic protein 2 isoform 7
NM_014670.4	NP_055485.2	eIF5-mimic protein 2 isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of translational initiation	IDA IDA: Inferred from direct assay	29470543	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10942595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BZW1 Protein Structure

W2

0
100
200
300
400
419 a.a.

Protein Preferred Names	Protein Names
eIF5-mimic protein 2	basic leucine zipper and W2 domain-containing protein 1

Related Diseases

Diseases	Alias
Salivary Gland Carcinoma	Salivary Gland Cancer Malignant Neoplasm Of Salivary Gland Salivary Gland Neoplasms
Eastern Equine Encephalitis	Eee Neuroinvasive Eastern Equine Encephalitis Virus Infection Eastern Equine Encephalomyelitis Encephalomyelitis, Eastern Equine Triple E Eastern Equine Encephalitis Virus Infection Neuroinvasive Eastern Equine Encephalitis Virus Disease Eee - [Eastern Equine Encephalitis]
Western Equine Encephalitis	Western Equine Encephalomyelitis Wee Encephalomyelitis, Western Equine Western Equine Encephalitis Virus Infection Wee - [Western Equine Encephalitis] Western Equine Encephalitis Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01689	BZW1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BZW1	VGNC	VGNC:84213
Felis catus	BZW1	VGNC	VGNC:60215
Canis familiaris	BZW1	VGNC	VGNC:38571
Mus musculus	BZW1	MGD	MGI:1914132
Bos taurus	BZW1	VGNC	VGNC:26612
Rattus norvegicus	BZW1	RGD	RGD:735129
Others	BZW1	NCBI