ST18 - ST18 C2H2C-type zinc finger transcription factor Gene

Also Known as NZF3; NZF-3; ZNF387; ZC2H2C3; ZC2HC10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9705

About ST18

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,110,838-52,409,879 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Biased expression in brain (RPKM 3.7), stomach (RPKM 0.7) and 3 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

ST18 Products (60)

mRNA Protein Name
NM_001352826.2 NP_001339755.1 suppression of tumorigenicity 18 protein isoform a
NM_001352827.2 NP_001339756.1 suppression of tumorigenicity 18 protein isoform a
NM_001352828.2 NP_001339757.1 suppression of tumorigenicity 18 protein isoform a
NM_001352829.2 NP_001339758.1 suppression of tumorigenicity 18 protein isoform a
NM_001352830.2 NP_001339759.1 suppression of tumorigenicity 18 protein isoform a
NM_001352831.2 NP_001339760.1 suppression of tumorigenicity 18 protein isoform a
NM_001352832.2 NP_001339761.1 suppression of tumorigenicity 18 protein isoform a
NM_001352833.2 NP_001339762.1 suppression of tumorigenicity 18 protein isoform a
NM_001352834.2 NP_001339763.1 suppression of tumorigenicity 18 protein isoform a
NM_001352835.2 NP_001339764.1 suppression of tumorigenicity 18 protein isoform a
NM_001352836.2 NP_001339765.1 suppression of tumorigenicity 18 protein isoform a
NM_001352837.2 NP_001339766.1 suppression of tumorigenicity 18 protein isoform a
NM_001352838.2 NP_001339767.1 suppression of tumorigenicity 18 protein isoform a
NM_001352839.2 NP_001339768.1 suppression of tumorigenicity 18 protein isoform a
NM_001352840.2 NP_001339769.1 suppression of tumorigenicity 18 protein isoform a
NM_001352841.2 NP_001339770.1 suppression of tumorigenicity 18 protein isoform a
NM_001352842.2 NP_001339771.1 suppression of tumorigenicity 18 protein isoform a
NM_001352843.2 NP_001339772.1 suppression of tumorigenicity 18 protein isoform a
NM_001352844.2 NP_001339773.1 suppression of tumorigenicity 18 protein isoform a
NM_001352845.2 NP_001339774.1 suppression of tumorigenicity 18 protein isoform a
NM_001352846.2 NP_001339775.1 suppression of tumorigenicity 18 protein isoform a
NM_001352847.2 NP_001339776.1 suppression of tumorigenicity 18 protein isoform a
NM_001352848.2 NP_001339777.1 suppression of tumorigenicity 18 protein isoform a
NM_001352849.2 NP_001339778.1 suppression of tumorigenicity 18 protein isoform a
NM_001352850.2 NP_001339779.1 suppression of tumorigenicity 18 protein isoform a
NM_001352851.2 NP_001339780.1 suppression of tumorigenicity 18 protein isoform a
NM_001352852.2 NP_001339781.1 suppression of tumorigenicity 18 protein isoform a
NM_001352853.2 NP_001339782.1 suppression of tumorigenicity 18 protein isoform a
NM_001352854.2 NP_001339783.1 suppression of tumorigenicity 18 protein isoform a
NM_001352855.2 NP_001339784.1 suppression of tumorigenicity 18 protein isoform a
NM_001352856.2 NP_001339785.1 suppression of tumorigenicity 18 protein isoform a
NM_001352857.2 NP_001339786.1 suppression of tumorigenicity 18 protein isoform a
NM_001352858.2 NP_001339787.1 suppression of tumorigenicity 18 protein isoform c
NM_001352859.2 NP_001339788.1 suppression of tumorigenicity 18 protein isoform c
NM_001352860.2 NP_001339789.1 suppression of tumorigenicity 18 protein isoform c
NM_001352861.2 NP_001339790.1 suppression of tumorigenicity 18 protein isoform b
NM_001352862.2 NP_001339791.1 suppression of tumorigenicity 18 protein isoform b
NM_001352863.2 NP_001339792.1 suppression of tumorigenicity 18 protein isoform b
NM_001352864.2 NP_001339793.1 suppression of tumorigenicity 18 protein isoform b
NM_001352865.2 NP_001339794.1 suppression of tumorigenicity 18 protein isoform b
NM_001352866.2 NP_001339795.1 suppression of tumorigenicity 18 protein isoform b
NM_001352867.2 NP_001339796.1 suppression of tumorigenicity 18 protein isoform b
NM_001352868.2 NP_001339797.1 suppression of tumorigenicity 18 protein isoform b
NM_001352869.2 NP_001339798.1 suppression of tumorigenicity 18 protein isoform b
NM_001352870.2 NP_001339799.1 suppression of tumorigenicity 18 protein isoform d
NM_001352871.2 NP_001339800.1 suppression of tumorigenicity 18 protein isoform d
NM_001352872.2 NP_001339801.1 suppression of tumorigenicity 18 protein isoform d
NM_001352873.2 NP_001339802.1 suppression of tumorigenicity 18 protein isoform d
NM_001352874.2 NP_001339803.1 suppression of tumorigenicity 18 protein isoform d
NM_001352875.2 NP_001339804.1 suppression of tumorigenicity 18 protein isoform d
NM_001352876.2 NP_001339805.1 suppression of tumorigenicity 18 protein isoform f
NM_001352877.2 NP_001339806.1 suppression of tumorigenicity 18 protein isoform e
NM_001352878.2 NP_001339807.1 suppression of tumorigenicity 18 protein isoform e
NM_001352879.1 NP_001339808.1 suppression of tumorigenicity 18 protein isoform g
NM_001352880.1 NP_001339809.1 suppression of tumorigenicity 18 protein isoform g
NM_001352881.1 NP_001339810.1 suppression of tumorigenicity 18 protein isoform g
NM_001352882.1 NP_001339811.1 suppression of tumorigenicity 18 protein isoform g
NM_001352883.2 NP_001339812.1 suppression of tumorigenicity 18 protein isoform h
NM_001352884.2 NP_001339813.1 suppression of tumorigenicity 18 protein isoform h
NM_014682.3 NP_055497.1 suppression of tumorigenicity 18 protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18676404 GOA
Biological Process GO Annotation Evidence References Source
involved in interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18676404 GOA
involved in interleukin-6-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18676404 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15489893 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
18676404 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18676404 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
18676404 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15489893 GOA
part of protein-DNA complex IDA
IDA: Inferred from direct assay
18676404 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST18 Protein Structure

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (366 - 394)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (410 - 439)

MYT1

MYT1: Myelin transcription factor 1 (480 - 716)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (723 - 751)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (765 - 795)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (813 - 843)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (868 - 895)

  • 0
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  • 1000
  • 1047 a.a.
Protein Preferred Names Protein Names

suppression of tumorigenicity 18 protein

  • ST18, C2H2C-type zinc finger

Related Diseases

Diseases Alias
Pemphigus
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13845 ST18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19643 St18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26136 St18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ST18 RGD RGD:708566
Felis catus ST18 VGNC VGNC:65718
Canis familiaris ST18 VGNC VGNC:46849
Bos taurus ST18 VGNC VGNC:35330
Macaca mulatta ST18 VGNC VGNC:77959
Mus musculus ST18 MGD MGI:2446700
Others ST18 NCBI