CTIF - cap binding complex dependent translation initiation factor Gene

Also Known as Gm672; KIAA0427

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9811

About CTIF

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:48,539,031-48,863,217 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele, 205 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 23.6), brain (RPKM 13.3) and 22 other tissues.

Summary

CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009]

CTIF Products (2)

mRNA Protein Name
NM_001142397.2 NP_001135869.1 CBP80/20-dependent translation initiation factor isoform 2
NM_014772.3 NP_055587.1 CBP80/20-dependent translation initiation factor isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19648179 GOA
Biological Process GO Annotation Evidence References Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
IMP: Inferred from mutant phenotype
19648179 GOA
involved in regulation of translational initiation IMP
IMP: Inferred from mutant phenotype
19648179 GOA
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19648179 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTIF Protein Structure

MIF4G

MIF4G: MIF4G domain (379 - 576)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
Protein Preferred Names Protein Names

CBP80/20-dependent translation initiation factor

Related Diseases

Diseases Alias
Orofacial Cleft 11

  • OFC11

  • Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 11

  • Nonsyndromic Cleft Lip With Or Without Cleft Palate 11

  • Non-Syndromic Orofacial Cleft 11

  • Chcl

  • Cleft Lip Congenital Healed

  • Congenital Healed Cleft Lip

  • Non-Syndromic Cleft Lip/Palate 11

  • Non-Syndromic Cleft Lip With Or Without Cleft Palate 11

  • Orofacial Cleft, Type 11

  • Cleft Lip, Congenital Healed
Hernia, Hiatus

  • Hiatal Hernia

  • Hiatus Hernia

  • Diaphragmatic - Hiatus -Hernia

  • Hernia, Hiatal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03298 CTIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CTIF RGD RGD:1311887
Canis familiaris CTIF VGNC VGNC:39698
Mus musculus CTIF MGD MGI:2685518
Bos taurus CTIF VGNC VGNC:27797
Felis catus CTIF VGNC VGNC:61252
Macaca mulatta CTIF VGNC VGNC:110334
Others CTIF NCBI