PJA2 - praja ring finger ubiquitin ligase 2 Gene

Also Known as RNF131; Neurodap1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9867

About PJA2

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:109,334,722-109,409,974 (from NCBI)

This gene has 4 transcripts (splice variants), 155 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 108.1), thyroid (RPKM 63.6) and 24 other tissues.

Summary

Enables protein kinase A catalytic subunit binding activity; protein kinase A regulatory subunit binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of macrophage activation; and regulation of signal transduction. Located in cytoplasm; intermediate filament cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PJA2 Products (1)

mRNA	Protein	Name
NM_014819.5	NP_055634.3	E3 ubiquitin-protein ligase Praja-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28471450	GOA
enables protein kinase A catalytic subunit binding	IMP IMP: Inferred from mutant phenotype	21423175	GOA
enables protein kinase A regulatory subunit binding	IMP IMP: Inferred from mutant phenotype	21423175	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	33934390	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	21423175	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in innate immune response	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in positive regulation of toll-like receptor 2 signaling pathway	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	33934390	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	21423175	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	28471450	GOA
involved in regulation of protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	21423175	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	33934390	GOA
located in centrosome	IDA IDA: Inferred from direct assay	33934390	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21423175	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21423175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PJA2 Protein Structure

zf-RING_2

0
200
400
600
708 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase Praja-2	RING-type E3 ubiquitin transferase Praja-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10589	PJA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PJA2	VGNC	VGNC:75817
Mus musculus	PJA2	MGD	MGI:2159342
Rattus norvegicus	PJA2	RGD	RGD:620273
Canis familiaris	PJA2	VGNC	VGNC:44595
Bos taurus	PJA2	VGNC	VGNC:32931
Felis catus	PJA2	VGNC	VGNC:64191