SNAP91 - synaptosome associated protein 91 Gene
Also Known as CALM; AP180
Species: Homo sapiens
About SNAP91
This gene has 22 transcripts (splice variants), 265 orthologues and 1 paralogue. Biased expression in brain (RPKM 42.7), testis (RPKM 6.2) and 1 other tissue.
Summary
Predicted to enable several functions, including SNARE binding activity; clathrin binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
SNAP91 Products (68)
| mRNA | Protein | Name |
|---|---|---|
| NM_001242792.2 | NP_001229721.1 | clathrin coat assembly protein AP180 isoform a |
| NM_001242793.2 | NP_001229722.1 | clathrin coat assembly protein AP180 isoform b |
| NM_001242794.2 | NP_001229723.1 | clathrin coat assembly protein AP180 isoform c |
| NM_001256717.2 | NP_001243646.1 | clathrin coat assembly protein AP180 isoform d |
| NM_001256718.2 | NP_001243647.1 | clathrin coat assembly protein AP180 isoform e |
| NM_001363677.2 | NP_001350606.1 | clathrin coat assembly protein AP180 isoform f |
| NM_001376675.1 | NP_001363604.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376676.1 | NP_001363605.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376677.1 | NP_001363606.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376678.1 | NP_001363607.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376679.1 | NP_001363608.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376680.1 | NP_001363609.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376681.1 | NP_001363610.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376682.1 | NP_001363611.1 | clathrin coat assembly protein AP180 isoform g |
| NM_001376683.1 | NP_001363612.1 | clathrin coat assembly protein AP180 isoform h |
| NM_001376684.1 | NP_001363613.1 | clathrin coat assembly protein AP180 isoform h |
| NM_001376685.1 | NP_001363614.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376686.1 | NP_001363615.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376687.1 | NP_001363616.1 | clathrin coat assembly protein AP180 isoform gg |
| NM_001376688.1 | NP_001363617.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376689.1 | NP_001363618.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376690.1 | NP_001363619.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376691.1 | NP_001363620.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376692.1 | NP_001363621.1 | clathrin coat assembly protein AP180 isoform i |
| NM_001376693.1 | NP_001363622.1 | clathrin coat assembly protein AP180 isoform j |
| NM_001376694.1 | NP_001363623.1 | clathrin coat assembly protein AP180 isoform k |
| NM_001376695.1 | NP_001363624.1 | clathrin coat assembly protein AP180 isoform l |
| NM_001376696.1 | NP_001363625.1 | clathrin coat assembly protein AP180 isoform l |
| NM_001376697.1 | NP_001363626.1 | clathrin coat assembly protein AP180 isoform l |
| NM_001376698.1 | NP_001363627.1 | clathrin coat assembly protein AP180 isoform l |
| NM_001376699.1 | NP_001363628.1 | clathrin coat assembly protein AP180 isoform m |
| NM_001376700.1 | NP_001363629.1 | clathrin coat assembly protein AP180 isoform m |
| NM_001376701.1 | NP_001363630.1 | clathrin coat assembly protein AP180 isoform n |
| NM_001376702.1 | NP_001363631.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376703.1 | NP_001363632.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376704.1 | NP_001363633.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376705.1 | NP_001363634.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376706.1 | NP_001363635.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376707.1 | NP_001363636.1 | clathrin coat assembly protein AP180 isoform o |
| NM_001376708.1 | NP_001363637.1 | clathrin coat assembly protein AP180 isoform b |
| NM_001376709.1 | NP_001363638.1 | clathrin coat assembly protein AP180 isoform b |
| NM_001376710.1 | NP_001363639.1 | clathrin coat assembly protein AP180 isoform b |
| NM_001376711.1 | NP_001363640.1 | clathrin coat assembly protein AP180 isoform b |
| NM_001376712.1 | NP_001363641.1 | clathrin coat assembly protein AP180 isoform hh |
| NM_001376713.1 | NP_001363642.1 | clathrin coat assembly protein AP180 isoform p |
| NM_001376714.1 | NP_001363643.1 | clathrin coat assembly protein AP180 isoform p |
| NM_001376715.1 | NP_001363644.1 | clathrin coat assembly protein AP180 isoform q |
| NM_001376716.1 | NP_001363645.1 | clathrin coat assembly protein AP180 isoform r |
| NM_001376717.1 | NP_001363646.1 | clathrin coat assembly protein AP180 isoform s |
| NM_001376718.1 | NP_001363647.1 | clathrin coat assembly protein AP180 isoform t |
| NM_001376719.1 | NP_001363648.1 | clathrin coat assembly protein AP180 isoform u |
| NM_001376720.1 | NP_001363649.1 | clathrin coat assembly protein AP180 isoform v |
| NM_001376721.1 | NP_001363650.1 | clathrin coat assembly protein AP180 isoform v |
| NM_001376723.1 | NP_001363652.1 | clathrin coat assembly protein AP180 isoform v |
| NM_001376726.1 | NP_001363655.1 | clathrin coat assembly protein AP180 isoform v |
| NM_001376728.1 | NP_001363657.1 | clathrin coat assembly protein AP180 isoform v |
| NM_001376731.1 | NP_001363660.1 | clathrin coat assembly protein AP180 isoform w |
| NM_001376733.1 | NP_001363662.1 | clathrin coat assembly protein AP180 isoform x |
| NM_001376734.1 | NP_001363663.1 | clathrin coat assembly protein AP180 isoform x |
| NM_001376735.1 | NP_001363664.1 | clathrin coat assembly protein AP180 isoform y |
| NM_001376736.1 | NP_001363665.1 | clathrin coat assembly protein AP180 isoform z |
| NM_001376737.1 | NP_001363666.1 | clathrin coat assembly protein AP180 isoform aa |
| NM_001376738.1 | NP_001363667.1 | clathrin coat assembly protein AP180 isoform bb |
| NM_001376739.1 | NP_001363668.1 | clathrin coat assembly protein AP180 isoform cc |
| NM_001376740.1 | NP_001363669.1 | clathrin coat assembly protein AP180 isoform dd |
| NM_001376741.1 | NP_001363670.1 | clathrin coat assembly protein AP180 isoform ee |
| NM_001376742.1 | NP_001363671.1 | clathrin coat assembly protein AP180 isoform ff |
| NM_014841.3 | NP_055656.1 | clathrin coat assembly protein AP180 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17762867 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within regulation of clathrin-dependent endocytosis |
IMP
IMP: Inferred from mutant phenotype
|
16254249 | GOA |
SNAP91 Protein Structure
ANTH: ANTH domain (21 - 284)
- 0
- 200
- 400
- 600
- 800
- 907 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
clathrin coat assembly protein AP180 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Myopathy, Centronuclear, 2 |
|
|
| Cataract 8, Multiple Types |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Parkinson Disease, Late-Onset |
|
|