SNAP91 - synaptosome associated protein 91 Gene

Also Known as CALM; AP180

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9892

About SNAP91

Cytogenetic location: 6q14.2 Genomic coordinates (GRCh38): 6:83,552,885-83,709,393 (from NCBI)

This gene has 22 transcripts (splice variants), 265 orthologues and 1 paralogue. Biased expression in brain (RPKM 42.7), testis (RPKM 6.2) and 1 other tissue.

Summary

Predicted to enable several functions, including SNARE binding activity; clathrin binding activity; and phosphatidylinositol binding activity. Acts upstream of or within regulation of clathrin-dependent endocytosis. Predicted to be located in several cellular components, including postsynaptic density; presynaptic endosome; and presynaptic membrane. Predicted to be extrinsic component of endosome membrane. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

SNAP91 Products (68)

mRNA Protein Name
NM_001242792.2 NP_001229721.1 clathrin coat assembly protein AP180 isoform a
NM_001242793.2 NP_001229722.1 clathrin coat assembly protein AP180 isoform b
NM_001242794.2 NP_001229723.1 clathrin coat assembly protein AP180 isoform c
NM_001256717.2 NP_001243646.1 clathrin coat assembly protein AP180 isoform d
NM_001256718.2 NP_001243647.1 clathrin coat assembly protein AP180 isoform e
NM_001363677.2 NP_001350606.1 clathrin coat assembly protein AP180 isoform f
NM_001376675.1 NP_001363604.1 clathrin coat assembly protein AP180 isoform g
NM_001376676.1 NP_001363605.1 clathrin coat assembly protein AP180 isoform g
NM_001376677.1 NP_001363606.1 clathrin coat assembly protein AP180 isoform g
NM_001376678.1 NP_001363607.1 clathrin coat assembly protein AP180 isoform g
NM_001376679.1 NP_001363608.1 clathrin coat assembly protein AP180 isoform g
NM_001376680.1 NP_001363609.1 clathrin coat assembly protein AP180 isoform g
NM_001376681.1 NP_001363610.1 clathrin coat assembly protein AP180 isoform g
NM_001376682.1 NP_001363611.1 clathrin coat assembly protein AP180 isoform g
NM_001376683.1 NP_001363612.1 clathrin coat assembly protein AP180 isoform h
NM_001376684.1 NP_001363613.1 clathrin coat assembly protein AP180 isoform h
NM_001376685.1 NP_001363614.1 clathrin coat assembly protein AP180 isoform i
NM_001376686.1 NP_001363615.1 clathrin coat assembly protein AP180 isoform i
NM_001376687.1 NP_001363616.1 clathrin coat assembly protein AP180 isoform gg
NM_001376688.1 NP_001363617.1 clathrin coat assembly protein AP180 isoform i
NM_001376689.1 NP_001363618.1 clathrin coat assembly protein AP180 isoform i
NM_001376690.1 NP_001363619.1 clathrin coat assembly protein AP180 isoform i
NM_001376691.1 NP_001363620.1 clathrin coat assembly protein AP180 isoform i
NM_001376692.1 NP_001363621.1 clathrin coat assembly protein AP180 isoform i
NM_001376693.1 NP_001363622.1 clathrin coat assembly protein AP180 isoform j
NM_001376694.1 NP_001363623.1 clathrin coat assembly protein AP180 isoform k
NM_001376695.1 NP_001363624.1 clathrin coat assembly protein AP180 isoform l
NM_001376696.1 NP_001363625.1 clathrin coat assembly protein AP180 isoform l
NM_001376697.1 NP_001363626.1 clathrin coat assembly protein AP180 isoform l
NM_001376698.1 NP_001363627.1 clathrin coat assembly protein AP180 isoform l
NM_001376699.1 NP_001363628.1 clathrin coat assembly protein AP180 isoform m
NM_001376700.1 NP_001363629.1 clathrin coat assembly protein AP180 isoform m
NM_001376701.1 NP_001363630.1 clathrin coat assembly protein AP180 isoform n
NM_001376702.1 NP_001363631.1 clathrin coat assembly protein AP180 isoform o
NM_001376703.1 NP_001363632.1 clathrin coat assembly protein AP180 isoform o
NM_001376704.1 NP_001363633.1 clathrin coat assembly protein AP180 isoform o
NM_001376705.1 NP_001363634.1 clathrin coat assembly protein AP180 isoform o
NM_001376706.1 NP_001363635.1 clathrin coat assembly protein AP180 isoform o
NM_001376707.1 NP_001363636.1 clathrin coat assembly protein AP180 isoform o
NM_001376708.1 NP_001363637.1 clathrin coat assembly protein AP180 isoform b
NM_001376709.1 NP_001363638.1 clathrin coat assembly protein AP180 isoform b
NM_001376710.1 NP_001363639.1 clathrin coat assembly protein AP180 isoform b
NM_001376711.1 NP_001363640.1 clathrin coat assembly protein AP180 isoform b
NM_001376712.1 NP_001363641.1 clathrin coat assembly protein AP180 isoform hh
NM_001376713.1 NP_001363642.1 clathrin coat assembly protein AP180 isoform p
NM_001376714.1 NP_001363643.1 clathrin coat assembly protein AP180 isoform p
NM_001376715.1 NP_001363644.1 clathrin coat assembly protein AP180 isoform q
NM_001376716.1 NP_001363645.1 clathrin coat assembly protein AP180 isoform r
NM_001376717.1 NP_001363646.1 clathrin coat assembly protein AP180 isoform s
NM_001376718.1 NP_001363647.1 clathrin coat assembly protein AP180 isoform t
NM_001376719.1 NP_001363648.1 clathrin coat assembly protein AP180 isoform u
NM_001376720.1 NP_001363649.1 clathrin coat assembly protein AP180 isoform v
NM_001376721.1 NP_001363650.1 clathrin coat assembly protein AP180 isoform v
NM_001376723.1 NP_001363652.1 clathrin coat assembly protein AP180 isoform v
NM_001376726.1 NP_001363655.1 clathrin coat assembly protein AP180 isoform v
NM_001376728.1 NP_001363657.1 clathrin coat assembly protein AP180 isoform v
NM_001376731.1 NP_001363660.1 clathrin coat assembly protein AP180 isoform w
NM_001376733.1 NP_001363662.1 clathrin coat assembly protein AP180 isoform x
NM_001376734.1 NP_001363663.1 clathrin coat assembly protein AP180 isoform x
NM_001376735.1 NP_001363664.1 clathrin coat assembly protein AP180 isoform y
NM_001376736.1 NP_001363665.1 clathrin coat assembly protein AP180 isoform z
NM_001376737.1 NP_001363666.1 clathrin coat assembly protein AP180 isoform aa
NM_001376738.1 NP_001363667.1 clathrin coat assembly protein AP180 isoform bb
NM_001376739.1 NP_001363668.1 clathrin coat assembly protein AP180 isoform cc
NM_001376740.1 NP_001363669.1 clathrin coat assembly protein AP180 isoform dd
NM_001376741.1 NP_001363670.1 clathrin coat assembly protein AP180 isoform ee
NM_001376742.1 NP_001363671.1 clathrin coat assembly protein AP180 isoform ff
NM_014841.3 NP_055656.1 clathrin coat assembly protein AP180 isoform a
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17762867 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
16254249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNAP91 Protein Structure

ANTH

ANTH: ANTH domain (21 - 284)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 907 a.a.
Protein Preferred Names Protein Names

clathrin coat assembly protein AP180

  • 91 kDa synaptosomal-associated protein

Related Diseases

Diseases Alias
Myopathy, Centronuclear, 2
  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2

Cataract 8, Multiple Types
  • Ccv

  • Cataract, Congenital, Volkmann Type

  • CTRCT8

  • Cataract 8 Multiple Types

  • Cataract Congenital Volkmann Type

  • Cutaneous Collagenous Vasculopathy

Alzheimer Disease, Familial, 1
  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers

Parkinson Disease, Late-Onset
  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus SNAP91 VGNC VGNC:65518
Rattus norvegicus SNAP91 RGD RGD:69276
Bos taurus SNAP91 VGNC VGNC:59365
Canis familiaris SNAP91 VGNC VGNC:46590
Mus musculus SNAP91 MGD MGI:109132
Macaca mulatta SNAP91 VGNC VGNC:77711