ARHGAP44 - Rho GTPase activating protein 44 Gene

Also Known as RICH2; NPC-A-10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9912

About ARHGAP44

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:12,789,498-12,991,643 (from NCBI)

This gene has 11 transcripts (splice variants), 269 orthologues and 2 paralogues. Broad expression in brain (RPKM 18.3), colon (RPKM 17.1) and 20 other tissues.

Summary

Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP44 Products (5)

mRNA Protein Name
NM_001321164.2 NP_001308093.1 rho GTPase-activating protein 44 isoform 2
NM_001321166.2 NP_001308095.1 rho GTPase-activating protein 44 isoform 3
NM_001321167.2 NP_001308096.1 rho GTPase-activating protein 44 isoform 4
NM_001321168.2 NP_001308097.1 rho GTPase-activating protein 44 isoform 5
NM_014859.6 NP_055674.4 rho GTPase-activating protein 44 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phospholipid binding IDA
IDA: Inferred from direct assay
22750946 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19273615 GOA
Cellular Component GO Annotation Evidence References Source
located in leading edge membrane IDA
IDA: Inferred from direct assay
22750946 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP44 Protein Structure

BAR

BAR: BAR domain (1 - 241)

RhoGAP

RhoGAP: RhoGAP domain (271 - 415)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 44

  • Rho-type GTPase-activating protein RICH2

Related Diseases

Diseases Alias
Apolipoprotein C-Iii Deficiency

  • Hyperalphalipoproteinemia 2

  • HALP2
Phobia, Specific

  • Specific Phobia

  • Simple Phobia

  • Phobia, Simple

  • Isolated Phobia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00937 ARHGAP44 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGAP44 RGD RGD:1305664
Canis familiaris ARHGAP44 VGNC VGNC:38065
Felis catus ARHGAP44 VGNC VGNC:59893
Bos taurus ARHGAP44 VGNC VGNC:26097
Mus musculus ARHGAP44 MGD MGI:2144423
Macaca mulatta ARHGAP44 VGNC VGNC:99117