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CRYZL1 - crystallin zeta like 1 Gene

Also Known as 4P11; QOH-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9946

About CRYZL1

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,589,341-33,641,741 (from NCBI)

This gene has 23 transcripts (splice variants), 228 orthologues and 17 paralogues. Ubiquitous expression in testis (RPKM 17.7), brain (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]

CRYZL1 Products (1)

mRNA	Protein	Name
NM_145858.3	NP_665857.2	quinone oxidoreductase-like protein 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	37267906	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26496610	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome	IDA IDA: Inferred from direct assay	37267905	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRYZL1 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
349 a.a.

Protein Preferred Names	Protein Names
quinone oxidoreductase-like protein 1	crystallin, zeta (quinone reductase)-like 1

Related Diseases

Diseases	Alias
Chromosome 16p11.2 Duplication Syndrome	Proximal 16p11.2 Microduplication Syndrome Proximal Dup(16)(P11.2) Proximal Trisomy 16p11.2 Autism, Susceptibility To, 14b Autism 14b
Bardet-Biedl Syndrome 3	BBS3 Bardet-Biedl Syndrome, Type 3
Extraosseous Osteosarcoma	Extraskeletal Osteosarcoma Extraskeletal Osteogenic Sarcoma
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03220	CRYZL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CRYZL1	VGNC	VGNC:27747
Macaca mulatta	CRYZL1	VGNC	VGNC:81297
Mus musculus	CRYZL1	MGD	MGI:1913859
Felis catus	CRYZL1	VGNC	VGNC:61210
Rattus norvegicus	CRYZL1	RGD	RGD:1310219
Others	CRYZL1	NCBI