1. Protein Tyrosine Kinase/RTK
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    c-Kit
    PDGFR
  3. Henatinib

Henatinib 

Cat. No.: HY-13645
Handling Instructions

Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs).

For research use only. We do not sell to patients.

Henatinib Chemical Structure

Henatinib Chemical Structure

CAS No. : 1239269-51-2

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Description

Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs)[1].

IC50 & Target

VEGFR-2

0.6 nM (IC50)

PDGFRα

 

PDGFRβ

 

In Vitro

Henatinib shows high binding affinities for VEGFRs, PDGFR and stem cell factor receptor[1].
Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs), and consistently inhibited VEGF-stimulated HUVEC proliferation, migration and tubule formation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.52

Formula

C25H29FN4O4

CAS No.
SMILES

O=C1N(C[[email protected]](O)CN2CCOCC2)CCCC3=C1C(C)=C(/C=C4C(NC5=C\4C=C(F)C=C5)=O)N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Henatinib
Cat. No.:
HY-13645
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