NLGN2 - neuroligin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57555

About NLGN2

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,404,653-7,419,860 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 237 orthologues and 13 paralogues. Broad expression in brain (RPKM 29.8), endometrium (RPKM 15.7) and 20 other tissues.

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

NLGN2 Products (1)

mRNA Protein Name
NM_020795.4 NP_065846.1 neuroligin-2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
22528485 GOA
acts upstream of or within positive regulation of protein localization to synapse IDA
IDA: Inferred from direct assay
24613359 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLGN2 Protein Structure

COesterase

COesterase: Carboxylesterase family (40 - 601)

  • 0
  • 200
  • 400
  • 600
  • 835 a.a.
Protein Preferred Names Protein Names

neuroligin-2

Related Diseases

Diseases Alias
Pitt-Hopkins-Like Syndrome 1

  • Cortical Dysplasia-Focal Epilepsy Syndrome

  • CDFES

  • PTHSL1

  • Cdfe Syndrome

  • Pitt-Hopkins Like Syndrome 1

  • Pitt-Hopkins-Like Syndrome-1

  • Cntnap2-Related Developmental And Epileptic Encephalopathy

  • Cntnap2-Related Dee

  • Mesh

  • D006985

  • Mesh

  • D008607
Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Pervasive Developmental Disorders

  • Pervasive Child Development Disorders

  • Autistic Behavior

  • Autism Spectrum Disorders
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09340 NLGN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22679 Nlgn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29193 Nlgn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NLGN2 MGD MGI:2681835
Felis catus NLGN2 VGNC VGNC:63822
Canis familiaris NLGN2 VGNC VGNC:43839
Bos taurus NLGN2 VGNC VGNC:55861
Macaca mulatta NLGN2 VGNC VGNC:104635
Rattus norvegicus NLGN2 RGD RGD:621118
Others NLGN2 NCBI