1. Metabolic Enzyme/Protease
  2. ATP Citrate Lyase
    HIF/HIF Prolyl-Hydroxylase
  3. Hydroxycitric acid tripotassium hydrate

Hydroxycitric acid tripotassium hydrate (Synonyms: Potassium citrate monohydrate)

Cat. No.: HY-W009156 Purity: >98.0%
Handling Instructions

Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects.

For research use only. We do not sell to patients.

Hydroxycitric acid tripotassium hydrate Chemical Structure

Hydroxycitric acid tripotassium hydrate Chemical Structure

CAS No. : 6100-05-6

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10 mM * 1 mL in Water USD 105 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia and a derivative of citric acid. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects[1][2][3][4].

In Vitro

Hydroxycitric acid shows an HIF inhibitory effect compared with the control group in ARPE19 cells and 661W cells. Hydroxycitric acid can downregulate Hif1a and the downstream genes in ARPE19 cells and 661W cells. Hydroxycitric acid suppresses HIF-1α protein expression increased by CoCl2 administration in ARPE19 cells and 661W cells[2].
In chicken hepatocytes, Hydroxycitric acid decreases the accumulation of lipid droplets and accelerated energy metabolism. Hydroxycitric acid protects the cells from ER stress by increasing the antioxidant status and mitochondrial functions[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Hydroxycitric acid (100-200 mg/kg) treatment could reduce markers of renal impairment (Blood Urea Nitrogen and serum creatinine). There is significantly less calcium oxalate crystal deposition in mice (male C57BL/6J mice) treated with Hydroxycitric acid. Hydroxycitric acid attenuates the oxidative stress induced by calcium oxalate crystallization. Hydroxycitric acid has inhibitory effects on calcium oxalate-induced inflammatory cytokines, such as MCP-1, IL-1 β, and IL-6. In addition, Hydroxycitric acid alleviates tubular injury and apoptosis caused by calcium oxalate crystals[1].
The administration of Hydroxycitric acid can suppress body weight gain and fat accumulation in animals[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

324.41

Formula

C₆H₇K₃O₈

CAS No.

6100-05-6

SMILES

O=C(O[K])CC(C(O[K])=O)(O)CC(O[K])=O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 120 mg/mL (369.90 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0825 mL 15.4126 mL 30.8252 mL
5 mM 0.6165 mL 3.0825 mL 6.1650 mL
10 mM 0.3083 mL 1.5413 mL 3.0825 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

Hydroxycitric acid tripotassiumPotassium citrateATP Citrate LyaseHIF/HIF Prolyl-HydroxylaseACLYHypoxia-inducible factorsHIFsHIF-PHCitratecleavageextramitochondrialCaOxstonessafetyantioxidationanti-inflammationHIF-1αATPInhibitorinhibitorinhibit

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Product Name:
Hydroxycitric acid tripotassium hydrate
Cat. No.:
HY-W009156
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