ID110460002
ID110460002 possesses both full agonist activity at the μ-opioid receptor (OPRM) and agonist activity at the δ-opioid receptor (OPRD). ID110460002 acts as a potent agonist for the G protein pathways of both receptors, but exhibits only very weak partial agonist activity towards the β-arrestin-2 pathway. The agonistic potency of ID110460002 at OPRM has extremely high intrinsic activity and is unaffected by reduced receptor expression levels, while its potency at OPRD depends on receptor expression levels. ID110460002 displays tissue- or organ-dependent properties, and serves as a critical compound for investigating pain mechanisms and analgesia.
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- CAS No.: 1172882-21-1
- Formule: C20H25FN4O
- Masse moléculaire:356.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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μ Opioid Receptor/MOR |
δ Opioid Receptor/DOR |
Arrestin-3/β-Arrestin 2 |
In Vitro
ID110460002 acts as a full G protein agonist in HEK-293 cells overexpressing OPRM, with high intrinsic activity that resists receptor depletion, and exhibits an Emax of 77.8% upon treatment with 10 nM β-FNA (HY-160938)[1].
ID110460002 acts as a very weak partial agonist of the β-arrestin2 pathway in HEK-293 cells overexpressing OPRM, with an Emax of 15.3% relative to DAMGO (HY-P0210)[1].
ID110460002 acts as a partial G protein agonist in HEK-293 cells overexpressing OPRD, and its potency decreases with reduced receptor abundance; when treated with 1000 nM β-CNA (HY-141468), its Emax reaches 64.6%[1].
ID110460002 acts as a very weak partial agonist of the β-arrestin2 pathway in HEK-293 cells overexpressing OPRD, with an Emax of 4.7% relative to SNC80 (HY-101202)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1172882-21-1
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Masse moléculaire 356.45
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Formule C20H25FN4O
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SMILES
O=C(NC1=CC=C(F)C=C1)NCC(C2=CC=C3C(=C2)CCN3C)N(C)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ID110460002 Related Classifications
HY-W414109 Related Classifications
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