1172882-21-1
Chemical Structure
ID110460002
- CAS No.: 1172882-21-1
- Formula:C20H25FN4O
- Molecular Weight:356.45
IUPAC Name: 1-(2-(dimethylamino)-2-(1-methylindolin-5-yl)ethyl)-3-(4-fluorophenyl)urea
InChIKey: HCVDSQAUSTUSGJ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(F)C=C1)NCC(C2=CC=C3C(=C2)CCN3C)N(C)C
Biological Activity: ID110460002 possesses both full agonist activity at the μ-opioid receptor (OPRM) and agonist activity at the δ-opioid receptor (OPRD). ID110460002 acts as a potent agonist for the G protein pathways of both receptors, but exhibits only very weak partial agonist activity towards the β-arrestin-2 pathway. The agonistic potency of ID110460002 at OPRM has extremely high intrinsic activity and is unaffected by reduced receptor expression levels, while its potency at OPRD depends on receptor expression levels. ID110460002 displays tissue- or organ-dependent properties, and serves as a critical compound for investigating pain mechanisms and analgesia[1].
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ID110460002 | ID110460002 possesses both full agonist activity at the μ-opioid receptor (OPRM) and agonist activity at the δ-opioid receptor (OPRD). ID110460002 acts as a potent agonist for the G protein pathways of both receptors, but exhibits only very weak partial agonist activity towards the β-arrestin-2 pathway. The agonistic potency of ID110460002 at OPRM has extremely high intrinsic activity and is unaffected by reduced receptor expression levels, while its potency at OPRD depends on receptor expression levels. ID110460002 displays tissue- or organ-dependent properties, and serves as a critical compound for investigating pain mechanisms and analgesia. | |||||||||||||||||||||
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Keywords
