CYP4F2 - cytochrome P450 family 4 subfamily F member 2 Gene

Also Known as CPF2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8529

About CYP4F2

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,878,023-15,898,074 (from NCBI)

This gene has 8 transcripts (splice variants), 433 orthologues and 12 paralogues. Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of Cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]

CYP4F2 Products (1)

mRNA	Protein	Name
NM_001082.5	NP_001073.3	cytochrome P450 4F2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alkane 1-monooxygenase activity	IDA IDA: Inferred from direct assay	18433732	GOA
enables alpha-tocopherol omega-hydroxylase activity	IDA IDA: Inferred from direct assay	20861217	GOA
enables arachidonate epoxygenase activity	IDA IDA: Inferred from direct assay	9618440	GOA
enables arachidonate omega-hydroxylase activity	IDA IDA: Inferred from direct assay	9618440	GOA
enables leukotriene-B4 20-monooxygenase activity	IDA IDA: Inferred from direct assay	8026587	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	15145985	GOA
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	IDA IDA: Inferred from direct assay	19297519	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17474147	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	10660572	GOA
involved in epoxygenase P450 pathway	IDA IDA: Inferred from direct assay	9618440	GOA
involved in fatty acid omega-oxidation	IDA IDA: Inferred from direct assay	18577768	GOA
involved in leukotriene B4 catabolic process	IDA IDA: Inferred from direct assay	8026587	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	18433732	GOA
involved in menaquinone catabolic process	IDA IDA: Inferred from direct assay	24138531	GOA
involved in negative regulation of icosanoid secretion	IMP IMP: Inferred from mutant phenotype	18391101	GOA
involved in omega-hydroxylase P450 pathway	IDA IDA: Inferred from direct assay	9799565	GOA
involved in phylloquinone catabolic process	IDA IDA: Inferred from direct assay	24138531	GOA
involved in positive regulation of icosanoid secretion	IMP IMP: Inferred from mutant phenotype	17341693	GOA
involved in pressure natriuresis	IEP IEP: Inferred from expression pattern	10660572	GOA
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	18391101	GOA
involved in renal water homeostasis	IEP IEP: Inferred from expression pattern	10660572	GOA
involved in sodium ion homeostasis	IEP IEP: Inferred from expression pattern	10660572	GOA
involved in very long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	18433732	GOA
involved in vitamin E metabolic process	IDA IDA: Inferred from direct assay	20861217	GOA
involved in vitamin K catabolic process	IDA IDA: Inferred from direct assay	19297519	GOA
involved in xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	21084764	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10660572	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10660572	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	9618440	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP4F2 Protein Structure

p450

0
100
200
300
400
520 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 4F2	20-HETE synthase

CYP4F2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CYP4F2	P78329	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	CYP4F2	P78329	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	CYP4F2	P78329	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	CYP4F2	P78329	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	CYP4F2	P78329	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	CYP4F2	P78329	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	CYP4F2	P78329	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	CYP4F2	P78329	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	CYP4F2	P78329	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	CYP4F2	P78329	REEP2	Homo sapiens	Q9BRK0	Y2H Array	32296183
Intra	CYP4F2	P78329	REEP2	Homo sapiens	Q9BRK0	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	REEP2	Homo sapiens	Q9BRK0	Validated Y2H	32296183
Intra	CYP4F2	P78329	ZDHHC15	Homo sapiens	Q96MV8	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	ZDHHC15	Homo sapiens	Q96MV8	Validated Y2H	32296183
Intra	CYP4F2	P78329	ZDHHC15	Homo sapiens	Q96MV8	Y2H Array	32296183
Intra	CYP4F2	P78329	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	CYP4F2	P78329	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	CYP4F2	P78329	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	CYP4F2	P78329	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	CYP4F2	P78329	SCN3B	Homo sapiens	Q9NY72	Validated Y2H	32296183
Intra	CYP4F2	P78329	SCN3B	Homo sapiens	Q9NY72	Y2H Array	32296183
Intra	CYP4F2	P78329	SCN3B	Homo sapiens	Q9NY72	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SLC17A8	Homo sapiens	Q8NDX2-2	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SLC17A8	Homo sapiens	Q8NDX2-2	Validated Y2H	32296183
Intra	CYP4F2	P78329	SLC17A8	Homo sapiens	Q8NDX2-2	Y2H Array	32296183
Intra	CYP4F2	P78329	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	CYP4F2	P78329	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	CYP4F2	P78329	TSPAN31	Homo sapiens	Q12999	Validated Y2H	32296183
Intra	CYP4F2	P78329	TSPAN31	Homo sapiens	Q12999	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	TSPAN31	Homo sapiens	Q12999	Y2H Array	32296183
Intra	CYP4F2	P78329	MMD	Homo sapiens	Q15546	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	MMD	Homo sapiens	Q15546	Validated Y2H	32296183
Intra	CYP4F2	P78329	MMD	Homo sapiens	Q15546	Y2H Array	32296183
Intra	CYP4F2	P78329	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	CYP4F2	P78329	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	CYP4F2	P78329	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	CYP4F2	P78329	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	CYP4F2	P78329	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SLC2A13	Homo sapiens	Q96QE2	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SLC2A13	Homo sapiens	Q96QE2	Validated Y2H	32296183
Intra	CYP4F2	P78329	SLC2A13	Homo sapiens	Q96QE2	Y2H Array	32296183
Intra	CYP4F2	P78329	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	CYP4F2	P78329	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	CYP4F2	P78329	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	CYP4F2	P78329	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	CYP4F2	P78329	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	CYP4F2	P78329	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	CYP4F2	P78329	DNAJC1	Homo sapiens	Q96KC8	Validated Y2H	32296183
Intra	CYP4F2	P78329	DNAJC1	Homo sapiens	Q96KC8	Y2H Array	32296183
Intra	CYP4F2	P78329	NCK1	Homo sapiens	P16333	Peptide Array	17474147
Intra	CYP4F2	P78329	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	CYP4F2	P78329	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	CYP4F2	P78329	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	CYP4F2	P78329	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	CYP4F2	P78329	SLC19A3	Homo sapiens	Q9BZV2	Y2H Array	32296183
Intra	CYP4F2	P78329	SLC19A3	Homo sapiens	Q9BZV2	Validated Y2H	32296183
Intra	CYP4F2	P78329	SLC19A3	Homo sapiens	Q9BZV2	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	CYP4F2	P78329	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	CYP4F2	P78329	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	CYP4F2	P78329	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	CYP4F2	P78329	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	CYP4F2	P78329	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	CYP4F2	P78329	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	CYP4F2	P78329	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	CYP4F2	P78329	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	CYP4F2	P78329	SDHAF2	Homo sapiens	Q9NX18	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	SDHAF2	Homo sapiens	Q9NX18	Validated Y2H	32296183
Intra	CYP4F2	P78329	SDHAF2	Homo sapiens	Q9NX18	Y2H Array	32296183
Intra	CYP4F2	P78329	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	CYP4F2	P78329	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	CYP4F2	P78329	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	CYP4F2	P78329	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183
Intra	CYP4F2	P78329	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	CYP4F2	P78329	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	CYP4F2	P78329	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	CYP4F2	P78329	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	CYP4F2	P78329	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	CYP4F2	P78329	ROM1	Homo sapiens	Q03395	Validated Y2H	32296183
Intra	CYP4F2	P78329	ROM1	Homo sapiens	Q03395	Y2H Array	32296183
Intra	CYP4F2	P78329	ROM1	Homo sapiens	Q03395	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183
Intra	CYP4F2	P78329	PLEKHO1	Homo sapiens	Q53GL0	Validated Y2H	32296183
Intra	CYP4F2	P78329	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Thrombosis	Thrombosis Of Blood Vessel
Inflammatory Bowel Disease 6	IBD6
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156876	20-HETE inhibitor-2	Inhibitor	99.17%	Unkown
HY-151810	TP0472993	Inhibitor	98.22%	Unkown
HY-151809	CYP4A11/CYP4F2-IN-1	Inhibitor	99.82%	Unkown
HY-149770	CYP4A11/CYP4F2-IN-2	Inhibitor	/	Unkown
HY-RS03480	CYP4F2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Others	CYP4F2	NCBI