Carmaphycin-17
Carmaphycin-17 (CP-17) is a selective 20S proteasome inhibitor with an EC50 of 217 ?nM. Carmaphycin-17 has potent antimicrobial activity against Trichomonas vaginalis. Carmaphycin-17 overcomes Metronidazole (HY-B0318) resistance and significantly reduces parasite burden upon topical treatment without any apparent adverse effects in vaginal trichomonad infection mice model. Carmaphycin-17 can be used for sexually transmitted disease like trichomoniasis research.
For research use only. We do not sell to patients.
- CAS No.: 2143080-91-3
- Formula: C40H45N5O5
- Molecular Weight:675.82
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Parasite Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
346 nM
Compound: 17
|
Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay
Cytotoxicity against human HepG2 cells harboring A16-CD81EGFP assessed as cell viability after 48 hrs by bioluminescence assay
|
[PMID: 28696697] |
Chemical Information
-
CAS No. 2143080-91-3
-
Molecular Weight 675.82
-
Formula C40H45N5O5
-
SMILES
O=C([C@]1(CO1)C)[C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H](NC(CCCCC)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CNC6=CC=CC=C56)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Carmaphycin-17 Related Classifications
HY-171956 Related Classifications
Powered by Bioz