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Apc - APC regulator of WNT signaling pathway Gene

Also Known as RATAPC

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24205

About Apc

Primary_assembly 18: 25,864,222-25,922,696 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 169 orthologues, 1 paralogue and is associated with 90 phenotypes. Biased expression in Brain (RPKM 51.2), Lung (RPKM 138.6) and 9 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of cardiac muscle cell proliferation; and regulation of glutamate metabolic process. Located in several cellular components, including axonal growth cone; cell body fiber; and lateral plasma membrane. Part of protein-containing complex. Colocalizes with neuron projection and synapse. Used to study anemia; colon adenocarcinoma; colon cancer; and familial adenomatous polyposis. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial Cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of Wnt signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]

Apc Products (1)

mRNA	Protein	Name
NM_012499.1	NP_036631.1	adenomatous polyposis coli protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	12610628	RGD
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	15670646	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9786987	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19858196	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	22399805	RGD
involved in establishment or maintenance of cell polarity	IDA IDA: Inferred from direct assay	12610628	RGD
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28948298	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	16303851	RGD
involved in pancreas development	IEP IEP: Inferred from expression pattern	16688812	RGD
involved in regulation of glutamate metabolic process	IDA IDA: Inferred from direct assay	19858196	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	18945221	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11689703	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	15670646	RGD
located in cell body fiber	IDA IDA: Inferred from direct assay	23001297	RGD
located in cell cortex	IDA IDA: Inferred from direct assay	18042042	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15670646	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16303851	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	15670646	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	8638125	RGD
located in microtubule	IDA IDA: Inferred from direct assay	16767746	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	18042042	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8638125	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	18042042	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19858196	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8638125	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Apc Protein Structure

Suppressor_APC

ARM

APC_rep

ARM

Arm

ARM

Arm_APC_u3

APC_u5

APC_r

APC_u9

APC_r

APC_u13

SAMP

APC_u14

APC_u15

SAMP

APC_basic

EB1_binding

0
500
1000
1500
2000
2500
2870 a.a.

Protein Preferred Names	Protein Names
adenomatous polyposis coli protein	APC, WNT signaling pathway regulator WNT signaling pathway regulator adenomatosis polyposis coli

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112968	Human protein C		/	Unkown

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124955	proTAME	Inhibitor	98.20%	Unkown
HY-110287	Apcin	Inhibitor	99.62%	Unkown
HY-130257	CP5V	Degrader	99.31%	Unkown
HY-13255	TAME	Inhibitor	99.51%	Unkown
HY-130841	Apcin-A	Inhibitor	98.0%	Unkown
HY-P1918	Activated Protein C (390-404), human		98.74%	Unkown
HY-13255A	TAME hydrochloride	Inhibitor	98.14%	Unkown
HY-122142A	Pyr-Pro-Arg-pNA (hydrochloride)	Substrate	99.24%	Unkown
HY-126016	MAI-400	Inhibitor	/	Unkown
HY-P1918A	Activated Protein C (390-404), human TFA		/	Unkown
HY-116473	CFM-1	Antagonist	/	Unkown
HY-179012	CDC20/HSP90-IN-1	Inhibitor	/	Unkown
HY-172401	CDC20-IN-2	Inhibitor	/	Unkown
HY-182052	Ferroptosis inducer-16	Inhibitor	/	Unkown
HY-112968A	Bovine Protein C		/	Unkown
HY-122142	Pyr-Pro-Arg-pNA	Substrate	/	Unkown
HY-W614725	Apcin-A monohydrochloride	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992193	Anti-B7-H7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apc	NCBI	NCBI:324