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Icrucumab

(Synonyms: Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1)
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Based on 1 publication(s) in Google Scholar

Icrucumab (Anti-VEGFR1/FLT1 Reference Antibody; IMC-18F1) is an IgG1 antibody inhibitor targeting VEGFR-1/FLT1 with anti-tumor activity. By blocking ligand-dependent phosphorylation and downstream signal transduction, Icrucumab reduces the activities of MAPK and Akt in breast cancer xenograft models, inhibits the proliferation and invasion of VEGFR-1-positive tumor cells, and reverses the conversion of M1 macrophages to the pro-tumor M2-like phenotype. Icrucumab also inhibits tumor cell proliferation, promotes apoptosis, and effectively suppresses tumor growth through direct targeting of tumors and host support mechanisms. In addition, Icrucumab exhibits a synergistic effect when combined with chemotherapeutic agents, and it is used in research related to various cancers including advanced solid malignancies, thyroid cancer, melanoma, and lung cancer.

For research use only. We do not sell to patients.

  • Purity: 99.9%
  • CAS No.: 1024603-92-6
  • Molecular Weight:146.68 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Icrucumab
  • Experimental Validation Results for Icrucumab
  • Experimental Validation Results for Icrucumab
  • Icrucumab Chemical Structure
    Icrucumab Chemical Structure
CAS No.: 1024603-92-6
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Icrucumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All VEGFR Isoforms

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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized VEGFR-1 Protein, Human (328a.a, HEK293, His, HY-P73065) can bind Icrucumab. The EC50 for this effect is 5.461 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HUVEC cells with Icrucumab (HY-P99364, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Icrucumab Chemical Structure
    1/16
  • Icrucumab
  • Immobilized VEGFR-1 Protein, Human (328a.a, HEK293, His, HY-P73065) can bind Icrucumab. The EC50 for this effect is 5.461 ng/mL.
  • Flow cytometric analysis of 1X106 HUVEC cells with Icrucumab (HY-P99364, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).