Soyasaponin Bb
Based on 1 publication(s) in Google Scholar
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 51330-27-9
- Formula: C48H78O18
- Molecular Weight:943.12
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Apoptosis Compound Library
HY-L003
-
Immunology/Inflammation Compound Library
HY-L007
-
Metabolism/Protease Compound Library
HY-L012
-
NF-κB Signaling Compound Library
HY-L014
-
Natural Product Library
HY-L021
-
Anti-Aging Compound Library
HY-L034
-
Antioxidant Compound Library
HY-L037
-
Glycoside Compound Library
HY-L042
-
Oxygen Sensing Compound Library
HY-L045
-
Ferroptosis Compound Library
HY-L051
-
Medicine Food Homology Compound Library
HY-L055
-
Terpenoids Library
HY-L056
-
Orally Active Compound Library
HY-L061
-
Traditional Chinese Medicine Active Compound Library
HY-L065
-
Neuroprotective Compound Library
HY-L070
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
Anti-Obesity Compound Library
HY-L087
-
Glucose Metabolism Compound Library
HY-L092
-
Food-Sourced Compound Library
HY-L094
-
Anti-inflammatory Traditional Chinese Medicine Active Compound Library
HY-L114
-
Plant-Sourced Natural Product Library
HY-L115
-
Human Metabolite Library
HY-L123
-
Mitochondrial Protection Compound Library
HY-L144
-
Metabolic Enzyme Compound Library
HY-L146
-
Cell Death Library
HY-L162
-
Radioprotector Library
HY-L178
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Anti-Fibrosis Compound Library
HY-L185
-
Miao Ethnicity Medicine Compound Library
HY-L190
-
Tibetan Medicine Compound Library
HY-L191
-
Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library
HY-L194
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library
HY-L209
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
Diarrhea-Related Traditional Chinese Medicine Active Compound Library
HY-L224
-
Mongolian Medicine Compound Library
HY-L238
-
Tonifying Traditional Chinese Medicine Monomer Compound Library
HY-L246
-
Lactylation Compound Library
HY-L249
-
Mass Spectrometry Natural Product Library
HY-L262
Publications Citing Use of MedChemExpress (MCE) Soyasaponin Bb
More
Biological Activity
|
HO-1 |
Soyasaponin Bb (25-100 μg/mL; pretreatment for 24 h + ethanol treatment for 24 h) increases cell viability, reduces reactive oxygen species (ROS) levels, increases superoxide dismutase (SOD) and glutathione (GSH) activities, downregulates malondialdehyde (MDA) and alanine aminotransferase (ALT) levels, and induces heme oxygenase-1 (HO-1) expression in rat hepatocyte BRL 3A assay[1].
Soyasaponin Bb (2.36-94.30 mg/L; 4 h) shows no significant cytotoxicity in the Caco-2 intestinal epithelial cell experiment. Soyasaponin Bb has an apparent permeability (Papp) across the membrane of less than 1.0×10-6 cm/s), with the apical-to-basolateral (AP-BL) transport significantly higher than the basolateral-to-apical (BL-AP) transport, indicating that the cell permeation of Soyasaponin Bb is mainly passive transport[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Rat BRL 3A hepatocytes
-
Concentration:0, 25, 50, 100 μg/mL
-
Incubation Time:24 h pretreatment with Soyasaponin Bb, followed by 24 h ethanol (250 mmol/L) treatment
-
Result:Dose-dependently increased cell viability, with 50 and 100 μg/mL groups showing significant protection compared to the ethanol-alone group.
The 25 μg/mL group showed minimal improvement.
Soyasaponin Bb (10 mg/kg; oral administration; once a day; for 5 consecutive days) significantly improves passive avoidance, Y-maze and Morris water maze task performance in the Scopolamine (HY-N0296)-induced mouse memory impairment model, increases brain-derived neurotrophic factor (BDNF) expression and cyclic adenosine monophosphate response element binding protein (CREB) phosphorylation level, without inhibiting acetylcholinesterase (AChE) activity[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Scopolamine-induced ICR mice Memory Impairment Model (male; 18-22 g, 5 weeks old)[3]
-
Dosage:10 mg/kg
-
Administration:Oral gavage, once 1 hour before scopolamine injection, single dose
-
Result:Significantly increased the latency time to enter the dark compartment in the retention trial, restoring memory impairment to 97% of the untreated normal control level, comparable to the positive control tacrine (10 mg/kg).
No significant differences were observed during the acquisition trial.
Chemical Information
-
CAS No. 51330-27-9
-
Appearance Solid
-
Molecular Weight 943.12
-
Formula C48H78O18
-
Color White to off-white
-
SMILES
O[C@H]([C@H]1O[C@@]2([H])[C@H](O[C@]3([H])O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)[C@H](O)[C@@H](C(O)=O)O[C@@]1([H])O[C@@H]4[C@@](CO)(C)[C@]5([H])CC[C@@]6(C)[C@]7(C)CC[C@@]8(C)[C@H](O)CC(C)(C)C[C@@]8([H])C7=CC[C@]6([H])[C@@]5(C)CC4
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Food Chem
Activation of bitter taste receptors by saponins and alkaloids identified in faba beans (Vicia faba L. minor). [Abstract]2023 Nov 15:426:136548. PMID: 37302309
Solvent & Solubility
DMSO : 100 mg/mL (106.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (285 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Lijie Z, et al. Soyasaponin Bb Protects Rat Hepatocytes from Alcohol-Induced Oxidative Stress by Inducing Heme Oxygenase-1. Pharmacogn Mag. 2016 Oct-Dec;12(48):302-306 [Content Brief]
[3]. Hong SW, et al. Soyasaponins Ab and Bb prevent scopolamine-induced memory impairment in mice without the inhibition of acetylcholinesterase. J Agric Food Chem. 2014 Mar 5;62(9):2062-8. [Content Brief]
[4]. Balestri F, et al. Soyasaponins from Zolfino bean as aldose reductase differential inhibitors. J Enzyme Inhib Med Chem. 2019 Dec;34(1):350-360. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0603 mL | 5.3016 mL | 10.6031 mL | 26.5078 mL |
| 5 mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 5.3016 mL | |
| 10 mM | 0.1060 mL | 0.5302 mL | 1.0603 mL | 2.6508 mL | |
| 15 mM | 0.0707 mL | 0.3534 mL | 0.7069 mL | 1.7672 mL | |
| 20 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3254 mL | |
| 25 mM | 0.0424 mL | 0.2121 mL | 0.4241 mL | 1.0603 mL | |
| 30 mM | 0.0353 mL | 0.1767 mL | 0.3534 mL | 0.8836 mL | |
| 40 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6627 mL | |
| 50 mM | 0.0212 mL | 0.1060 mL | 0.2121 mL | 0.5302 mL | |
| 60 mM | 0.0177 mL | 0.0884 mL | 0.1767 mL | 0.4418 mL | |
| 80 mM | 0.0133 mL | 0.0663 mL | 0.1325 mL | 0.3313 mL | |
| 100 mM | 0.0106 mL | 0.0530 mL | 0.1060 mL | 0.2651 mL |
Soyasaponin Bb Related Classifications
HY-N0310 Related Classifications
Powered by Bioz