Adenine-d
Based on 1 Customer Validation
Adenine-d is the deuterium labeled Adenine. Adenine (6-Aminopurine), a purine, is one of the four nucleobases in the nucleic acid of DNA. Adenine acts as a chemical component of DNA and RNA. Adenine also plays an important role in biochemistry involved in cellular respiration, the form of both ATP and the cofactors (NAD and FAD), and protein synthesis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.90%
- CAS 番号: 109923-52-6
- 分子式: C5H4DN5
- 分子量:136.13
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 109923-52-6
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非標識Cas 73-24-5
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性状 Solid
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分子量 136.13
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分子式 C5H4DN5
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Color White to off-white
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SMILES
[2H]C1=NC(N)=C2N=CNC2=N1
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別名
6-Aminopurine-d1; Vitamin B4-d1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
1 M HCl : 20 mg/mL (146.92 mM; Need ultrasonic)
DMSO : ≥ 10 mg/mL (73.46 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (14.69 mM; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;ORO J, et al. Synthesis of purines under possible primitive earth conditions. I. Adenine from hydrogen cyanide. Arch Biochem Biophys. 1961 Aug;94:217-27.;Griffiths AJF, et al. An Introduction to Genetic Analysis. 7th edition. New York: W. H. Freeman; 2000. Structure of DNA.;Reader V. The assay of vitamin B(4). Biochem J. 1930;24(6):1827-31. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO / 1 M HCl | 1 mM | 7.3459 mL | 36.7296 mL | 73.4592 mL | 183.6480 mL |
| 5 mM | 1.4692 mL | 7.3459 mL | 14.6918 mL | 36.7296 mL | |
| 10 mM | 0.7346 mL | 3.6730 mL | 7.3459 mL | 18.3648 mL | |
| DMSO / 1 M HCl | 15 mM | 0.4897 mL | 2.4486 mL | 4.8973 mL | 12.2432 mL |
| 20 mM | 0.3673 mL | 1.8365 mL | 3.6730 mL | 9.1824 mL | |
| 25 mM | 0.2938 mL | 1.4692 mL | 2.9384 mL | 7.3459 mL | |
| 30 mM | 0.2449 mL | 1.2243 mL | 2.4486 mL | 6.1216 mL | |
| 40 mM | 0.1836 mL | 0.9182 mL | 1.8365 mL | 4.5912 mL | |
| 50 mM | 0.1469 mL | 0.7346 mL | 1.4692 mL | 3.6730 mL | |
| 60 mM | 0.1224 mL | 0.6122 mL | 1.2243 mL | 3.0608 mL | |
| 1 M HCl | 80 mM | 0.0918 mL | 0.4591 mL | 0.9182 mL | 2.2956 mL |
| 100 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8365 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Adenine-d 関連分類
HY-B0152S 関連分類
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