Antileishmanial agent-22
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC50=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC50), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C29H26Cl2N4O3
- 分子量:549.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 0.408 μM (leishmanial), 0.038 μM (P. berghei); MIC: 28.44 μM (M. tuberculosis)[1]
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Cell Line
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Type | Value | Description | References |
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| Vero | CC50 |
455 μM
Compound: 15b
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Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
Cytotoxicity against African green monkey Vero cells incubated for 72 hrs by crystal violet staining based assay
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[PMID: 37269671] |
化学情報
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分子量 549.45
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分子式 C29H26Cl2N4O3
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SMILES
O=C(C1CCN(C(C)=O)CC1)NCC2=CC=C3CCC4=C(NC(C(C#N)=C4C5=C(Cl)C=CC(Cl)=C5)=O)C3=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antileishmanial agent-22 関連分類
HY-155846 関連分類
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