Antitrypanosomal agent 32
Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1916476-01-1
- 分子式: C16H19N3O2S
- 分子量:317.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
229 μM
Compound: 47
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Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
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[PMID: 27102161] |
Antitrypanosomal agent 32 (compound 2) inhibits Trypanosoma cruzi Tulahuen strain intracellular amastigotes in L929 cells with an IC50 of 5.4 μM and has a selectivity index of 46 relative to L929 cell cytotoxicity[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Dm28c-Luc strain intracellular amastigotes in Vero cells with an IC50 of 4.9 μM and IC90 of 36 μM, with selectivity indexes >61 and >8 respectively due to no detected cytotoxicity in Vero cells[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Y strain intracellular amastigotes in L6 cells with an IC50 of 0.16 μM and has a selectivity index of >1875 relative to L6 cell cytotoxicity[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi CL-Brener-Luc strain intracellular amastigotes in L6 cells with an IC50 of 0.036 μM and IC90 of 0.094 μM, with selectivity indexes >8333 and >3191 respectively due to no detected cytotoxicity in L6 cells[1].
Antitrypanosomal agent 32 (36-125 μM; 3 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi Dm28c-Luc strain in Vero cells, with 92.6% and 95.2% growth inhibition 3 days after washout from IC90 (36 μM) and 125 μM exposures respectively[1].
Antitrypanosomal agent 32 (0.094-1 μM; 10 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi CL-Brener-Luc strain in L6 cells, with 89.4% and 99.6% growth inhibition 10 days after washout from IC90 (0.094 μM) and 1 μM exposures respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, acute Chagas disease model infected with Trypanosoma cruzi CL-Brener-Luc trypomastigotes)[1]
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Dosage:10 mg/kg (first 5 days); 50 mg/kg (subsequent 5 days)
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Administration:i.p.; daily; 10 days
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Result:Reduced parasitemia persistently from day 7 post-infection throughout treatment.
Lowered parasitemia by about 50% at day 13 and maximally by 84% at day 17 post-infection.
Preserved steady body weight with no acute toxicity or mortality.
化学情報
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CAS 番号 1916476-01-1
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分子量 317.41
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分子式 C16H19N3O2S
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SMILES
O=C(N1CCOCC1)NCCC2=NC(C3=CC=CC=C3)=CS2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitrypanosomal agent 32 関連分類
HY-183747 関連分類
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