cis-THSG
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 928205-59-8
- 分子式: C20H22O9
- 分子量:406.38
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Topoisomerase アイソフォーム固有の製品をすべて表示
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生物活性
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Topoisomerase II |
cis-THSG (100 μM; 30 min) exhibits weak inhibitory activity against human DNA topoisomerase II, with 46% inhibition at 100 μM, and no activity against DNA topoisomerase I[1].
cis-THSG shows no cytotoxicity against HT-29, MCF-7, and HepG2 cell lines[1].
Cis-THSG (30-100 μM; 8 h) suppresses Dexamethasone (HY-14648)/8-CTP-cAMP -induced PEPCK mRNA expression in HepG2 cells, with maximum inhibition (61.7% reduction) observed at 30 μM for 8 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CF-1 (male; HFD-induced type 2 diabetes mellitus)[2]
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Dosage:0.01% in drinking water
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Administration:ad libitum; daily; 12 weeks
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Result:Significantly decreased serum glucose levels in HFD-induced diabetic mice.
Significantly lowered elevated serum insulin levels and reduced calculated HOMA-IR by 102.7% compared to the trans-THSG treatment group.
Greatly suppressed the sharp rise in blood glucose at 30 minutes post-intraperitoneal glucose injection and reduced the sustained high blood glucose levels observed at 120 minutes, effectively ameliorating glucose intolerance.
化学情報
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CAS 番号 928205-59-8
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分子量 406.38
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分子式 C20H22O9
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SMILES
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=C(/C=C\C3=CC=C(O)C=C3)C=C(O)C=C2O
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Xu ML, et al. A new stilbene glucoside from the roots of Polygonum multiflorum Thunb. Arch Pharm Res. 2006;29(11):946-951. [Content Brief]
[2]. Tang W, et al. Anti-diabetic activities of cis- and trans-2,3,5,4'-tetrahydroxystilbene 2-O-β-glucopyranoside from Polygonum multiflorum. Mol Nutr Food Res. 2017 Aug;61(8). [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
cis-THSG 関連分類
HY-N8250 関連分類
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