Cloperidone hydrochloride
Cloperidone hydrochloride acts as an inhibitor and substrate of CYP2C9, with an IC50 of 17.7 μM. Cloperidone hydrochloride exhibits enhanced cytotoxicity in cells expressing CYP2C9. It can be used in the research of sedative/hypnotic-related diseases.
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- CAS 番号: 525-26-8
- 分子式: C21H24Cl2N4O2
- 分子量:435.35
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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CYP2C9 17.7 μM (IC50) |
Cloperidone (0.3-100 μM; 6 min preincubation, 15 min incubation with substrate) hydrochloride potently inhibits recombinant CYP2C9 microsomes, with an IC50 of 17.7 μM[1].
Cloperidone (0-60 min) hydrochloride can be metabolized by recombinant CYP2C9 supersomes to produce a variety of distinct oxidative metabolites[1].
Cloperidone (100 μM) hydrochloride exhibits enhanced cytotoxicity in HepG2 cells expressing CYP2C9, reducing cell viability to 40% of the baseline level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 525-26-8
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分子量 435.35
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分子式 C21H24Cl2N4O2
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SMILES
O=C1NC2=C(C(N1CCCN3CCN(CC3)C4=CC(Cl)=CC=C4)=O)C=CC=C2.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Goldwaser E, et al. Machine learning-driven identification of drugs inhibiting cytochrome P450 2C9. PLoS Comput Biol. 2022 Jan 26;18(1):e1009820. [Content Brief]
[2]. Estrada E, et al. Designing sedative/hypnotic compounds from a novel substructural graph-theoretical approach. Journal of computer-aided molecular design. 1998 Nov;12(6):583-95. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cloperidone hydrochloride 関連分類
HY-164031A 関連分類
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