TBCB - tubulin folding cofactor B Gene

Also Known as CG22; CKAP1; CKAPI

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 1155

About TBCB

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,114,967-36,125,941 (from NCBI)

This gene has 15 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in brain (RPKM 27.7), testis (RPKM 13.9) and 25 other tissues.

Summary

Predicted to be involved in cell differentiation and nervous system development. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TBCB Products (2)

mRNA	Protein	Name
NM_001281.3	NP_001272.2	tubulin-folding cofactor B isoform 1
NM_001300971.3	NP_001287900.1	tubulin-folding cofactor B isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16303566	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasm	IDA IDA: Inferred from direct assay	22777741	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBCB Protein Structure

Ubiquitin_2

CAP_GLY

0
100
200
244 a.a.

Protein Preferred Names	Protein Names
tubulin-folding cofactor B	cytoskeleton associated protein 1

TBCB Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TBCB	Q99426	USP7	Homo sapiens	Q93009	Y2H Array	16713569
Intra	TBCB	Q99426	TUBA4A	Homo sapiens	P68366	Anti Tag CoIP	33961781
Intra	TBCB	Q99426	TUBA4A	Homo sapiens	P68366	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TBCB Proteins

製品番号	製品名	アクセッション番号	純度
HY-P77331	CKAP1/TBCB Protein, Human (His)	Q99426 (M1-I244)	≥ 90%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Kenny-Caffey Syndrome	Kenny Syndrome
Hypoparathyroidism-Retardation-Dysmorphism Syndrome	Sanjad-Sakati Syndrome Hrd Syndrome HRDS Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome Richardson-Kirk Syndrome Sss Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay Hypoparathyroidism With Short Stature, Mental Retardation And Seizures Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay
Neuronopathy, Distal Hereditary Motor, Type Viii	Autosomal Dominant Congenital Benign Spinal Muscular Atrophy HMN8 Dhmn8 Neuropathy, Distal Hereditary Motor, Type Viii Distal Hereditary Motor Neuronopathy Type 8 Autosomal Dominant Benign Distal Spinal Muscular Atrophy Congenital Benign Spinal Muscular Atrophy With Contractures Congenital Nonprogressive Spinal Muscular Atrophy Spinal Muscular Atrophy, Distal, Congenital Nonprogressive Spinal Muscular Atrophy, Congenital Benign, With Contractures Distal Hereditary Motor Neuropathy Type Viii Neuronopathy, Distal Hereditary Motor, 8 Distal Spinal Muscular Atrophy, Congenital Non-Progressive Spinal Muscular Atrophy Congenital Benign With Contractures
Retinitis Pigmentosa 2	RP2 X-Linked Retinitis Pigmentosa 2 Xlrp2 Xlrp-2 Retinitis Pigmentosa-2 Retinitis Pigmentosa, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14251	TBCB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19387	Tbcb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25879	Tbcb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	TBCB	RGD	RGD:1309965
Canis familiaris	TBCB	VGNC	VGNC:53996
Mus musculus	TBCB	MGD	MGI:1913661
Macaca mulatta	TBCB	VGNC	VGNC:97835
Bos taurus	TBCB	VGNC	VGNC:35649
Felis catus	TBCB	VGNC	VGNC:97655
Others	TBCB	NCBI