Pkp1 - plakophilin 1 Gene

Predicted to enable Cadherin binding activity and lamin binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; intermediate filament bundle assembly; and negative regulation of mRNA catabolic process. Predicted to act upstream of or within cell adhesion. Located in desmosome. Is expressed in alimentary system; larynx; sensory organ; skin; and urethra. Human ortholog(s) of this gene implicated in ectodermal dysplasia. Orthologous to human PKP1 (plakophilin 1). [provided by Alliance of Genome Resources, Apr 2022]