KCNJ9 - potassium inwardly rectifying channel subfamily J member 9 Gene

Also Known as GIRK3; KIR3.3

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3765

About KCNJ9

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:160,081,538-160,090,563 (from NCBI)

This gene has 1 transcript (splice variant), 186 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 8.9).

Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type Potassium Channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated Potassium Channel to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

KCNJ9 Products (1)

mRNA Protein Name
NM_004983.3 NP_004974.2 G protein-activated inward rectifier potassium channel 3
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12297500 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNJ9 Protein Structure

IRK

IRK: Inward rectifier potassium channel (25 - 347)

  • 0
  • 100
  • 200
  • 300
  • 393 a.a.
Protein Preferred Names Protein Names

G protein-activated inward rectifier potassium channel 3

  • G protein-coupled inward rectifier potassium channel

関連疾患

Diseases Alias
Deafness, Autosomal Dominant 7
  • DFNA7

  • Autosomal Dominant Nonsyndromic Deafness 7

  • Autosomal Dominant Deafness 7

  • Deafness, Autosomal Dominant, 7

  • Deafness, Autosomal Dominant, Type 7

Vitreoretinal Degeneration, Snowflake Type
  • Snowflake Vitreoretinal Degeneration

  • SVD

  • Snowflake Degeneration In Hereditary Vitreoretinal Degeneration

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus KCNJ9 VGNC VGNC:30464
Canis familiaris KCNJ9 VGNC VGNC:42269
Felis catus KCNJ9 VGNC VGNC:67918
Macaca mulatta KCNJ9 VGNC VGNC:106397
Rattus norvegicus KCNJ9 RGD RGD:621440
Mus musculus KCNJ9 MGD MGI:108007
Others KCNJ9 NCBI