RPN2 - ribophorin II Gene

Also Known as SWP1; RPNII; RIBIIR; RPN-II

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6185

About RPN2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,179,330-37,241,619 (from NCBI)

This gene has 9 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in thyroid (RPKM 122.3), placenta (RPKM 121.1) and 25 other tissues.

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose Oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein is similar in sequence to the yeast oligosaccharyl transferase subunit SWP1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

RPN2 Products (9)

mRNA Protein Name
NM_001135771.3 NP_001129243.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 2 precursor
NM_001324299.2 NP_001311228.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 3 precursor
NM_001324301.2 NP_001311230.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 4 precursor
NM_001324302.2 NP_001311231.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 5 precursor
NM_001324303.2 NP_001311232.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 6 precursor
NM_001324304.2 NP_001311233.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 7 precursor
NM_001324305.2 NP_001311234.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 8 precursor
NM_001324306.2 NP_001311235.1 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 9
NM_002951.5 NP_002942.2 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
24965446 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in protein N-linked glycosylation IDA
IDA: Inferred from direct assay
9642163 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of oligosaccharyltransferase complex IDA
IDA: Inferred from direct assay
9642163 GOA
part of oligosaccharyltransferase complex IPI
IPI: Inferred from physical interaction
31831667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPN2 Protein Structure

Ribophorin_II

Ribophorin_II: Oligosaccharyltransferase subunit Ribophorin II (3 - 628)

  • 0
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  • 500
  • 600
  • 631 a.a.
Protein Preferred Names Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit

Recombinant RPN2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P76574 RPN2/Ribophorin II Protein, Human (HEK293, Fc) P04844-1/NP_002942.2 (L23-V540) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76575 RPN2/Ribophorin II Protein, Human (HEK293, His) P04844-1/NP_002942.2 (L23-V540) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Encephalitozoonosis

  • Infection By Encephalitozoon
Microsporidiosis

  • Infection By Microspora

  • Microsporidiasis

  • Infection By Microsporea

  • Infection By Microsporida

  • Intestinal Microsporidiosis

  • Microsporidia Infection

  • Infection By Microsporidia
Facial Clefting, Oblique, 1

  • Oculomaxillofacial Dysostosis

  • Oculomaxillofacial Dysplasia With Oblique Facial Clefts

  • OBLFC1

  • Oblique Facial Clefting 1

  • Tessier Number 4 Facial Cleft

  • Oblique Facial Cleft

  • Orbitofacial Cleft

  • Oblique Facial Clefts

  • Richieri Costa Gorlin Syndrome

  • Richieri-Costa-Gorlin Syndrome

  • Facial Clefting, Oblique, Type 1
Teebi Hypertelorism Syndrome 1

  • Teebi Hypertelorism Syndrome

  • Brachycephalofrontonasal Dysplasia

  • Hypertelorism, Teebi Type

  • TBHS1

  • Tbhs

  • Chromosome 22q11.2 Deletion Syndrome, Opitz Phenotype

  • Opitz Gbbb Syndrome Type Ii

  • Specc1l-Related Hypertelorism Syndrome

  • Opitz Gbbb Syndrome, Type Ii, Formerly

  • Gbbb2, Formerly

  • Opitz Bbbg Syndrome, Type Ii, Formerly

  • Bbbg2, Formerly

  • Opitz-G Syndrome, Type Ii, Formerly

  • Ogs2, Formerly

  • Opitz Bbb Syndrome, Type Ii, Formerly

  • Hypertelorism-Hypospadias Syndrome, Formerly

  • Hypertelorism With Esophageal Abnormality And Hypospadias, Formerly

  • Opitz Oculogenitolaryngeal Syndrome, Type Ii, Formerly

  • Opitz-Frias Syndrome, Formerly

  • Teebi Hypertelorism Syndrome-1

  • Craniofrontonasal Dysplasia, Teebi Type

  • Bbb Syndrome

  • Gbbb Syndrome

  • G Syndrome

  • Hypertelorism-Hypospadias Syndrome

  • Hypertelorism With Esophageal Abnormality And Hypospadias

  • Hypospadias-Dysphagia Syndrome

  • Ogs2

  • Opitz Bbbg Syndrome

  • Opitz-Frias Syndrome

  • Opitz Gbbb Syndrome, Autosomal Dominant

  • Opitz-G Syndrome, Type Ii

  • Opitz Oculogenitolaryngeal Syndrome, Type Ii

  • Opitz Gbbb Syndrome, Type Ii

  • Teebi Syndrome

  • Opitz-G Syndrome, Type 2

  • Opitz Gbbb Syndrome, X-Linked

  • Digeorge Syndrome
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS11317 PSMD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12211 RPN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20813 Rpn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27327 Rpn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus RPN2 MGD MGI:98085
Felis catus RPN2 VGNC VGNC:64742
Canis familiaris RPN2 VGNC VGNC:45722
Bos taurus RPN2 VGNC VGNC:34120
Rattus norvegicus RPN2 RGD RGD:62075
Macaca mulatta RPN2 VGNC VGNC:76925
Others RPN2 NCBI