SELENOO - selenoprotein O Gene

Also Known as SELO

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 83642

About SELENOO

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,201,011-50,217,616 (from NCBI)

This gene has 2 transcripts (splice variants) and 243 orthologues. Ubiquitous expression in bone marrow (RPKM 10.3), liver (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

SELENOO Products (1)

mRNA Protein Name
NM_031454.2 NP_113642.1 protein adenylyltransferase SelO, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables AMPylase activity IDA
IDA: Inferred from direct assay
30270044 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in protein adenylylation IDA
IDA: Inferred from direct assay
30270044 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in mitochondrion IDA
IDA: Inferred from direct assay
24751718 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOO Protein Structure

UPF0061

UPF0061: Uncharacterized ACR, YdiU/UPF0061 family (85 - 627)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

protein adenylyltransferase SelO, mitochondrial

関連疾患

Diseases Alias
Staphyloenterotoxemia

  • Staphylococcal Food Poisoning

  • Staphylococcal Toxaemia Due To Food

  • Staphyloenterotoxicosis
Epidermolysis Bullosa Simplex 5a, Ogna Type

  • Epidermolysis Bullosa Simplex, Ogna Type

  • EBS5A

  • Ebsog

  • Epidermolysis Bullosa Simplex Ogna Type

  • Ebs-Og

  • Ebs-O

  • Plec-Related Intermediate Epidermolysis Bullosa Simplex Without Extracutaneous Involvement

  • Plec-Related Intermediate Ebs Without Extracutaneous Involvement

  • Ebs1

  • Ebso

  • Epidermolysis Bullosa Simplex 1

  • O-Ebs

  • Simplex Epidermolysis Bullosa_ogna Type
Commensal Bacterial Infectious Disease
Ritter'S Disease

  • Staphylococcal Scalded Skin Syndrome

  • Pemphigus Neonatorum

  • Ritter Disease

  • Dermatitis Exfoliativa Neonatorum

  • Scalded Skin Syndrome

  • Toxic Epidermal Necrolysis, Subcorneal Type

  • Generalized Exfoliative Disease

  • Ssss

  • Ssss - [Staphylococcal Scalded Skin Syndrome]
Rocky Mountain Spotted Fever

  • Brazillian Spotted

  • Choix

  • Exanthematic Typhus Of Sao Paulo

  • Fiebre Maculosa

  • Fiebre Manchada

  • Sao Paulo Typhus

  • So Paulo Fever

  • Tick Typhus

  • Tobia Fever

  • Rmsf

  • Typhus, Tick
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12640 SELENOO Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus SELENOO VGNC VGNC:109513
Bos taurus SELENOO VGNC VGNC:58445
Rattus norvegicus SELENOO RGD RGD:1311907
Mus musculus SELENOO MGD MGI:1919007
Canis familiaris SELENOO VGNC VGNC:54544
Macaca mulatta SELENOO VGNC VGNC:98474
Others SELENOO NCBI