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Mipomersen sodium

(別名: ISIS 301012)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH).

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  • CAS 番号: 629167-92-6
  • 分子量:7179.15 (free acid)
  • 保管条件:

    -20°C, stored under nitrogen, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

  • Mipomersen sodium Chemical Structure
    Mipomersen sodium 構造式
  • Experimental Validation Results for Mipomersen sodium
  • Experimental Validation Results for Mipomersen sodium
  • Experimental Validation Results for Mipomersen sodium
  • Experimental Validation Results for Mipomersen sodium
  • Experimental Validation Results for Mipomersen sodium
CAS 番号: 629167-92-6
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  • Mipomersen sodium Chemical Structure
    Mipomersen sodium Chemical Structure DNA, d(P-thio)([2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-A-G-T-m5C-T-G-m5C-T-T-m5C-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC), sodium salt (1:19)
    1/16
  • 1/16

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]

    Customer Validation
     Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 h (3H) and allowed recovery for 13 hr (3H13R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 3H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

  • 1/16

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]

    Customer Validation
     Effects of Lomitapide and Mipomersen on granulosa and theca cell viability under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 8 hr (8H) and allowed recovery for 8 hr (8H8R). Cells collected at indicated time points were used for viability analysis. *; significant effect by HS (vs. NC within the same pharmacological treatment at the same time point), #; significant effect by time (vs. 8H within the same thermal and pharmacological treatment), +; significant effect by Lom+Mip (vs. vehicle of the same thermal treatment at the same time), P < 0.05, n = 3.

  • 1/16

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]

    Customer Validation
     Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (MTTP and ApoB inhibitor, respectively, 2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery at 37°C for 13 hr (3H13R). Cells maintained at 37°C served as a neutral control (16H NC). Medium were collected for VLDL isolation and then used for VLDL-apoB determination through the ELISA method.

  • 1/16

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]

    Customer Validation
     Effects of Lomitapide and Mipomersen on neutral lipid and cholesterol content of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for neutral lipid staining by BODIPYTM493/503 and for cholesterol content determination using commercial kits.

  • 1/16

    Mipomersen sodium purchased from MedChemExpress. Usage Cited in: Poult Sci. 2025 Nov 19;105(1):106137. [Abstract]

    Customer Validation
     Effects of Lomitapide and Mipomersen on cell proliferation and inflammatory response of granulosa and theca cells under heat stress. Granulosa and theca cells were treated with Lomitapide (Lom) and Mipomersen (Mip) (2.5 μM for each) for 2 hr. After washout, cells were heat-stressed (HS, 42°C) for 3 hr (3H) and allowed recovery for 13 (3H13R). Cells collected at indicated time points were used for PCNA (proliferating cell nuclear antigen) and IL-1β (interleukin-1β) expression through Western blot analysis. Results were normalized to β-actin and expressed as ratios relative to the control (NC 16H or NC 8H).

  • DNA, d(P-thio)([2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]m5rC-A-G-T-m5C-T-G-m5C-T-T-m5C-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC), sodium salt (1:19)