NOTA-FZCD-3
Based on 1 Customer Validation
NOTA-FZCD-3 is a NOTA (HY-134418)-labeled FZCD-3 polypeptide precursor that targets cathepsin D (CTSD) with a KD of 0.65 μM. NOTA-FZCD-3 binds specifically to the active site of CTSD, exhibits rapid in vivo clearance properties, and remains stable in blood for more than 2 h. NOTA-FZCD-3 can be used in studies monitoring CTSD-positive tumors.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.43%
- 分子式: C59H107N11O18
- 分子量:1258.54
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cathepsin D 0.65 μM (Kd) |
[68Ga]Ga-NOTA-FZCD-3 (0.5-2 h; 37°C) remains stable for at least 2 hours at 37°C in normal saline and human serum, with no decomposition detected[1].
[68Ga]Ga-NOTA-FZCD-3 (0.5-2 h) is taken up by human breast cancer cell lines MCF-7, MDA-MB-468, MDA-MB-415 and MDA-MB-175VII in a time-dependent manner. The uptake level is directly correlated with endogenous CTSD expression, and a peak uptake rate of 1.45% is observed in MDA-MB-175VII cells at 1 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[68Ga]Ga-NOTA-FZCD-3 (2.5-7.4 MBq; intravenous injection; single administration) exhibits the highest tumor uptake rate and contrast in the MDA-MB-175VII breast cancer xenograft model, with a peak tumor-to-non-tissue ratio of 7.65 at 1 h post-injection[1].
[68Ga]Ga-NOTA-FZCD-3 (3.7-7.4 MBq; intravenous injection; single dose) achieves specific tumor uptake in A549 lung cancer xenografts, with an initial uptake of 2.47% ID/g at 0.5 h post-injection[1].
The uptake of [68Ga]Ga-NOTA-FZCD-3 (2.5-3.7 MBq; intravenous injection; single administration) in MDA-MB-175VII tumor xenografts is directly correlated with endogenous CTSD expression levels[1].
[68Ga]Ga-NOTA-FZCD-3 (intravenous injection; single dose) exhibits favorable biosafety in tumor-bearing BALB/c nude mice, with no organ toxicity detected 7 days post-injection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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性状 Solid
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分子量 1258.54
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分子式 C59H107N11O18
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Color White to off-white
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配列
Isovaleryl-Val-Thr-Leu-Thr-Leu-Lys-NOTA
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シーケンスの短縮
Isovaleryl‑VTLTLK-NOTA
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
純度とドキュメンテーション
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データシート (262 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
NOTA-FZCD-3 関連分類
HY-P11844 関連分類
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