OICR41114
OICR41114 is a WDR5 PROTAC degrader with an EC50 of 40 nM. OICR41114 binds both DCAF1 and WDR5, and its binding affinity for DCAF1 is significantly enhanced in the presence of WDR5 (KD increases from 59 nM to 5 nM). OICR41114 exerts antiproliferative effects on MV4-11 cells. OICR41114 can be used for the research of acute myeloid leukemia.
(Pink: WDR5 ligand (HY-141799); Blue: VHL ligand (HY-169390); Black: linker (HY-140210)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C70H83Cl2F6N9O15
- 分子量:1475.36
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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VHL |
OICR41114 (5.5 μM; 20 min) binds and stabilizes recombinant DCAF1 and WDR5 proteins individually, and forms a ternary complex with the combined protein mixture as measured by DSF[1].
OICR41114 (0.002-10 μM; 5 days) reduces viability of MV4-11 cells with an EC50 of 158 nM after 5 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1475.36
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分子式 C70H83Cl2F6N9O15
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SMILES
O=C(/C=C/C1=C(C(C(N[C@H](C2=CC=C(C(Cl)=C2)F)CC(N)=O)=O)=CN1)C3=C(C=C(C=C3)Cl)F)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(C4=CC=C(C(C5=CC=C(C(NC(C6=CNC(C=C6C(F)(F)F)=O)=O)=C5)N7C[C@H](N([C@H](C7)C)C)C)=C4)F)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
OICR41114 関連分類
HY-169389 関連分類
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