1 Result for "

Rapamycin-d3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Rapamycin-d3" in MCE Product Catalog:

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1 Cited Publications
製品番号: HY-10219S
CAS 番号: 392711-19-2
純度:  ≥93.0%
別名: Sirolimus-d3; AY-22989-d3; NSC 226080-d3
Rapamycin-d3 (Sirolimus-d3; AY-22989-d3; NSC 226080-d3) is the deuterated-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant [3] .
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