Swainsonine
Based on 1 publication(s) in Google Scholar
Swainsonine (Tridolgosir) is an natural indolizidine alkaloid, a potent and reversible α-mannosidase inhibitor. Swainsonine induces apoptosis and cell cycle arrest at G2/M phase. Swainsonine shows anti-tumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.95%
- CAS 番号: 72741-87-8
- 分子式: C8H15NO3
- 分子量:173.21
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Swainsonine
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生物活性
Swainsonine (0-40 μM; 12 h) shows antiproliferative activity in U251 and LN444 cells[2].
Swainsonine (30 μM; 12 h) induces apoptosis and cell cycle arrest at G2/M phase, and decreases the expression of CyclinD1 and CDK4 protein levels, increases the expression of p16 protein level[2].
Swainsonine (30 μM; 12 h) reduces glioma cell migration and invasion[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U251, LN444 cells
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Concentration:0, 10, 20, 30, 40 µM
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Incubation Time:12 h
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Result:Inhibited cell viability in a dose-dependent manner, and shows no cytotoxicity in normal brain cells.
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Cell Line:U251 cells
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Concentration:30 µM
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Incubation Time:12 h
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Result:Induced cell cycle arrest at G2/M phase.
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Cell Line:U251 cells
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Concentration:30 µM
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Incubation Time:12 h
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Result:Induced apoptosis with the cleaved-Caspase-3 and cleaved-Caspase-9 expression were obviously increased.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Eighty-seven sixty-day-old male C57BL/6 mice[3]
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Dosage:1 mg/kg (cisplatin; 0.25 mg/kg, i.p., every other day for 10 days)
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Administration:I.p.; twice daily for ten days
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Result:Showed a significant reduction in ascites volume of 63.5% was observed in mice and a significant reduction in the percentage of cells in the G0/G1, S and G2 phases.
化学情報
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CAS 番号 72741-87-8
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性状 Solid
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分子量 173.21
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分子式 C8H15NO3
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Color White to yellow
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SMILES
O[C@@H]1[C@H](O)CN2CCC[C@@H](O)[C@]12[H]
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別名
スワインソニン; Tridolgosir
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Microbiome
An iron-binding protein of entomopathogenic fungus suppresses the proliferation of host symbiotic bacteria. [Abstract]2024 Oct 15;12(1):202. PMID: 39407320
溶剤 & 溶解度
DMSO : 10 mg/mL (57.73 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 4.17 mg/mL (24.07 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Dorling PR, et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. Biochem J. 1980 Nov 1;191(2):649-51. [Content Brief]
[2]. Sun L, et al. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019 Mar 19;19(1):247. doi: 10.1186/s12885-019-5425-7. [Content Brief]
[3]. Santos FM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011 Sep 15;18(12):1096-101. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.7733 mL | 28.8667 mL | 57.7334 mL | 144.3335 mL |
| 5 mM | 1.1547 mL | 5.7733 mL | 11.5467 mL | 28.8667 mL | |
| 10 mM | 0.5773 mL | 2.8867 mL | 5.7733 mL | 14.4333 mL | |
| 15 mM | 0.3849 mL | 1.9244 mL | 3.8489 mL | 9.6222 mL | |
| 20 mM | 0.2887 mL | 1.4433 mL | 2.8867 mL | 7.2167 mL | |
| DMSO | 25 mM | 0.2309 mL | 1.1547 mL | 2.3093 mL | 5.7733 mL |
| 30 mM | 0.1924 mL | 0.9622 mL | 1.9244 mL | 4.8111 mL | |
| 40 mM | 0.1443 mL | 0.7217 mL | 1.4433 mL | 3.6083 mL | |
| 50 mM | 0.1155 mL | 0.5773 mL | 1.1547 mL | 2.8867 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Swainsonine 関連分類
HY-N6722 関連分類
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