TAT-N15
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2415370-74-8
- 分子式: C155H250N48O40S3
- 分子量:3522.14
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
化学情報
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CAS 番号 2415370-74-8
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分子量 3522.14
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分子式 C155H250N48O40S3
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配列
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Met-Met-Pro-Tyr-Ser-Thr-Glu-Leu-Ile-Phe-Tyr-Ile-Glu-Met-Asp-Pro
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シーケンスの短縮
YGRKKRRQRRRMMPYSTELIFYIEMDP
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Liu Y, et al. A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke[J]. Journal of Stroke and Cerebrovascular Diseases, 2024, 33(7): 107736. [Content Brief]
[2]. Wang T, et al. p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model[J]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321(1): L159-L173. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)