TRPC5-IN-6
TRPC5-IN-6 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC5-IN-6 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3047956-65-7
- 分子式: C18H16Cl2FN5O2
- 分子量:424.26
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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TRPC5 |
TRPC5-IN-6 (Compound 12) (30 μM, 24 h) shows low toxicity on liver cells and HK-2 kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepatocyte, HK-2 cell
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Concentration:3, 10, 30 μM
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Incubation Time:24 h
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Result:Didn’t affect cell growth on both primary cultured hepatocytes and HK-2 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male ICR mice[1].
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Dosage:10 mL/kg
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Administration:oral gavage (p.o.)
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Result:Was well and rapidly absorbed and mainly distributed in the colon, kidney, and liver[1].
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Animal Model:hypertensive renal injury rat model[1].
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Dosage:5, 10 mg/kg
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Administration:oral gavage (p.o.)
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Result:Suppressed levels of urinary protein and urinary albumin to creatinine ratio (UACR) and attenuated the degree of podocyte injury [1].
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Animal Model:C57 mice[1].
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Dosage:10 mL/kg, the final dose is 500 mg/kg
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Administration:oral gavage (p.o.)
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Result:Didn't cause death or abnormal behavior in mice[1].
化学情報
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CAS 番号 3047956-65-7
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分子量 424.26
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分子式 C18H16Cl2FN5O2
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SMILES
O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
TRPC5-IN-6 関連分類
HY-162584 関連分類
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