Antitrypanosomal agent 32
Antitrypanosomal agent 32 is a antitrypanosomal agent with nanomolar potency against multiple Trypanosoma cruzi strains, including CL-Brener, Y, Dm28c-Luc and Tulahuen. Antitrypanosomal agent 32 sustains inhibition of parasite growth after washing and reduces parasitemia levels in BALB/c mice. Antitrypanosomal agent 32 can be used for the research of trypanosome infection.
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- CAS No.: 1916476-01-1
- 화학식: C16H19N3O2S
- 분자량:317.41
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
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| L6 | IC50 |
229 μM
Compound: 47
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Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
Cytotoxicity against rat L6 cells measured after 70 hrs by alamar blue staining based fluorescence analysis
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[PMID: 27102161] |
Antitrypanosomal agent 32 (compound 2) inhibits Trypanosoma cruzi Tulahuen strain intracellular amastigotes in L929 cells with an IC50 of 5.4 μM and has a selectivity index of 46 relative to L929 cell cytotoxicity[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Dm28c-Luc strain intracellular amastigotes in Vero cells with an IC50 of 4.9 μM and IC90 of 36 μM, with selectivity indexes >61 and >8 respectively due to no detected cytotoxicity in Vero cells[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi Y strain intracellular amastigotes in L6 cells with an IC50 of 0.16 μM and has a selectivity index of >1875 relative to L6 cell cytotoxicity[1].
Antitrypanosomal agent 32 inhibits Trypanosoma cruzi CL-Brener-Luc strain intracellular amastigotes in L6 cells with an IC50 of 0.036 μM and IC90 of 0.094 μM, with selectivity indexes >8333 and >3191 respectively due to no detected cytotoxicity in L6 cells[1].
Antitrypanosomal agent 32 (36-125 μM; 3 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi Dm28c-Luc strain in Vero cells, with 92.6% and 95.2% growth inhibition 3 days after washout from IC90 (36 μM) and 125 μM exposures respectively[1].
Antitrypanosomal agent 32 (0.094-1 μM; 10 days post-washout) exhibits trypanocidal activity against Trypanosoma cruzi CL-Brener-Luc strain in L6 cells, with 89.4% and 99.6% growth inhibition 10 days after washout from IC90 (0.094 μM) and 1 μM exposures respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, acute Chagas disease model infected with Trypanosoma cruzi CL-Brener-Luc trypomastigotes)[1]
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Dosage:10 mg/kg (first 5 days); 50 mg/kg (subsequent 5 days)
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Administration:i.p.; daily; 10 days
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Result:Reduced parasitemia persistently from day 7 post-infection throughout treatment.
Lowered parasitemia by about 50% at day 13 and maximally by 84% at day 17 post-infection.
Preserved steady body weight with no acute toxicity or mortality.
Chemical Information
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CAS No. 1916476-01-1
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분자량 317.41
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화학식 C16H19N3O2S
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SMILES
O=C(N1CCOCC1)NCCC2=NC(C3=CC=CC=C3)=CS2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitrypanosomal agent 32 Related Classifications
HY-183747 Related Classifications
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