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Cat. No.: HY-12570

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CK2-IN-9

CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC₅₀ of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC₅₀ of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.

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CAS No.: 1461658-58-1
화학식: C₂₃H₂₉N₉O
분자량:447.54

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CK2-IN-9 Chemical Structure

CAS No.: 1461658-58-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Casein Kinase Isoforms :

All Wnt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	4 μM Compound: 7b	Inhibition of human ERG expressed in CHO cells by patch clamp assay Inhibition of human ERG expressed in CHO cells by patch clamp assay	[PMID: 26985319]
DLD-1	GI₅₀	0.08 μM Compound: 7b	Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay	[PMID: 26985319]
HCT-116	GI₅₀	0.03 μM Compound: 7b	Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay	[PMID: 26985319]
HCT-116	GI₅₀	0.03 μM Compound: Example 1	Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay	[PMID: 24900617]
Sf21	IC₅₀	<0.003 μM Compound: 7b	Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay	[PMID: 26985319]
SW-620	GI₅₀	0.03 μM Compound: 7b	Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay	[PMID: 26985319]

Chemical Information

CAS No. 1461658-58-1
분자량 447.54
화학식 C₂₃H₂₉N₉O
SMILES

O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dowling JE, et al. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett. 2016 Jan 20;7(3):300-5. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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CK2-IN-9

All Casein Kinase Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CK2-IN-9 Related Classifications

HY-12570 Related Classifications