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Cat. No.: HY-19252

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GR-4991W93

GR-4991W93 is an orally active partial agonist against 5HT_1B/1D receptor, with pIC₅₀ values of 6.95 and 7.80 against 5HT_1B and 5HT_1D, respectively. GR-4991W93 demonstrates potent inhibition of electrically evoked plasma extravasation in the guinea pig. GR-4991W93 can be used for migraine research.

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CAS No.: 171549-56-7
화학식: C₁₈H₂₃N₃O₂
분자량:313.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

GR-4991W93 Chemical Structure

CAS No.: 171549-56-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
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Classifications
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

5-HT_1B Receptor

6.95 (pIC₅₀)

5-HT_1D Receptor

7.80 (pIC₅₀)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 171549-56-7
분자량 313.39
화학식 C₁₈H₂₃N₃O₂
SMILES

CN(C)[C@H](C1)C[C@@H]1C2=CNC3=CC=C(C[C@@H]4NC(OC4)=O)C=C32
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jandu KS, et al. Discovery of 4-[3-(trans-3-dimethylaminocyclobutyl)-1H-indol-5-ylmethyl]-(4S)-oxazolidin-2-one (4991W93), a 5HT(1B/1D) receptor partial agonist and a potent inhibitor of electrically induced plasma extravasation. J Med Chem. 2001 Mar 1;44(5):681-93. [Content Brief]

Calculators

몰농도 계산기

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Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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GR-4991W93

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GR-4991W93 Related Classifications

HY-19252 Related Classifications