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Cat. No.: HY-101765

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GW 833972A

고객리뷰

Based on 1 Customer Validation

GW 833972A is a selective CB₂ receptor agonist with pEC₅₀ of the human CB₂ receptor for GW 833972A of 7.3, and its selectivity for the CB₂ receptor is approximately 1000 times higher than that for the CB₁ receptor. GW 833972A inhibits induced neuronal depolarization and suppresses coughing caused by citric acid in guinea pig models. GW 833972A can be used for the study of chronic cough.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.91%
CAS No.: 1092502-33-4
화학식: C₁₈H₁₄Cl₂F₃N₅O
분자량:444.24

보관:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

GW 833972A Chemical Structure

CAS No.: 1092502-33-4

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

hCB2-R

7.3 (pEC₅₀)

rat CB2-R

7.5 (pEC₅₀)

All Cannabinoid Receptor Isoforms :

In Vitro

GW 833972A (0.3-300 μM; 10 min) inhibits capsaicin-induced depolarization in humans and guinea pigs, and also inhibits prostaglandin E(2) and hypertonic saline induced depolarization of isolated vagus nerve in guinea pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GW 833972A (30 mg/kg, 2 mL/kg; i.p.; single dose 30 min before test) inhibits tussive response in conscious guinea pigs induced by citric acid. It also inhibits capsaicin-induced plasma protein exudation in the main bronchus^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1092502-33-4
Appearance Solid
분자량 444.24
화학식 C₁₈H₁₄Cl₂F₃N₅O
Color White to off-white
SMILES

O=C(C1=CN=C(NC2=CC=CC(Cl)=C2)N=C1C(F)(F)F)NCC3=CC=NC=C3.[H]Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (481 KB)
- English - EN (481 KB)
- Français - FR (481 KB)
- Deutsch - DE (481 KB)
- Norwegian - NO (481 KB)
- Español - ES (481 KB)
- Swedish - SV (481 KB)
- Italian - IT (481 KB)
- Korean - KR (481 KB)
- Portuguese - PT (481 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Belvisi MG, et al. Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways. Br J Pharmacol. 2008 Oct;155(4):547-57. [Content Brief]

Calculators

몰농도 계산기

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농도 희석 계산기

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
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GW 833972A

SR144528

Taranabant

CB2R PAM

GW 833972A (Standard)

JD-5037

Otenabant

AM281

Olorinab

CB1 antagonist 2

GW842166X

AM6545

NESS 0327

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GW 833972A

SR144528

Taranabant

CB2R PAM

GW 833972A (Standard)

JD-5037

Otenabant

AM281

Olorinab

CB1 antagonist 2

GW842166X

AM6545

NESS 0327

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

GW 833972A Related Classifications

HY-101765 Related Classifications